DDX58, DExD/H-box helicase 58

DDX58, DExD/H-box helicase 58

• DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases which are implicated in a number of cellular processes involving RNA binding and alteration of RNA secondary structure. This gene encodes a protein containing RNA helicase-DEAD box protein motifs and a caspase recruitment domain (CARD). It is involved in viral double-stranded (ds) RNA recognition and the regulation of immune response. [provided by RefSeq, Jul 2008]

• Gene Synonyms (antiviral innate immune response receptor RIG-I, DEAD (Asp-Glu-Ala-Asp) box polypeptide 58, DEAD box protein 58, DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide, RNA helicase RIG-I, probable ATP-dependent RNA helicase DDX58, retinoic acid-inducible gene 1 protein, retinoic acid-inducible gene I protein, RIG-I, RIG1, RIGI, RLR-1, SGMRT2,)
• NCBI Gene ID: 23586
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O95786
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

DExD/H-box helicase 58 interacts with:

• DExD/H-box helicase 58
  F-box and WD repeat domain containing 7
  FKBP prolyl isomerase 8
  immunity related GTPase M
  leucine rich repeat containing 25
  leucine rich repeat containing 59
  lysine methyltransferase 2E (inactive)
  mex-3 RNA binding family member C
  mitochondrial antiviral signaling protein
  NLR family CARD domain containing 5
  NOP53 ribosome biogenesis factor
  pleckstrin homology domain containing A4
  retinoic acid induced 14
  ring finger protein 122
  ring finger protein 135
  ring finger protein 31
  ring finger protein 34
  stimulator of interferon response cGAMP interactor 1
  TANK binding kinase 1
  tripartite motif containing 40
  tripartite motif-containing 25
  ubiquitin specific peptidase 21
  vir like m6A methyltransferase associated
  WD repeat domain 82
  WRN helicase interacting protein 1
  zinc finger CCHC-type containing 3
  zinc finger protein 598, E3 ubiquitin ligase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.