RNF8, ring finger protein 8

RNF8, ring finger protein 8

• The protein encoded by this gene contains a RING finger motif and an FHA domain. This protein has been shown to interact with several class II ubiquitin-conjugating enzymes (E2), including UBE2E1/UBCH6, UBE2E2, and UBE2E3, and may act as an ubiquitin ligase (E3) in the ubiquitination of certain nuclear proteins. This protein is also known to play a role in the DNA damage response and depletion of this protein causes cell growth inhibition and cell cycle arrest. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]

• Gene Synonyms (E3 ubiquitin-protein ligase RNF8, C3HC4-type zinc finger protein, RING-type E3 ubiquitin transferase RNF8, UBC13/UEV-interacting ring finger protein, ring finger protein (C3HC4 type) 8, ring finger protein 8, E3 ubiquitin protein ligase, hRNF8,)
• NCBI Gene ID: 9025
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O76064
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ring finger protein 8 interacts with:

• angiomotin like 2
  C2 calcium dependent domain containing 6
  calcium binding and coiled-coil domain 1
  centrosomal protein 44
  centrosomal protein 85
  checkpoint kinase 2
  coiled-coil domain containing 14
  coiled-coil domain containing 50
  coiled-coil domain containing 85B
  deoxynucleotidyltransferase terminal interacting protein 2
  DNA polymerase delta 4, accessory subunit
  epsin 2
  epsin 3
  exosome component 2
  family with sequence similarity 9 member B
  fibronectin type III and SPRY domain containing 2
  G protein-coupled receptor associated sorting protein 2
  homeobox and leucine zipper encoding
  jumonji domain containing 1C
  keratin associated protein 10-1
  keratin associated protein 10-8
  keratin associated protein 9-2
  keratin associated protein 9-8
  kinesin family member 24
  lysine demethylase 4A
  MAGE family member D1
  mediator of DNA damage checkpoint 1
  piwi like RNA-mediated gene silencing 1
  PNMA family member 2
  progesterone receptor membrane component 2
  protein interacting with PRKCA 1
  RAD50 double strand break repair protein
  ring finger protein 126
  ring finger protein 8
  RING1 and YY1 binding protein
  RNA binding fox-1 homolog 2
  septin 3
  septin 8
  sodium voltage-gated channel beta subunit 3
  TNFAIP3 interacting protein 1
  translocase of outer mitochondrial membrane 20 like
  transmembrane protein 79
  tripartite motif containing 29
  ubiquitin conjugating enzyme E2 E3
  ubiquitin conjugating enzyme E2 S
  ubiquitin conjugating enzyme E2 W
  ubiquitin specific peptidase 16
  WD repeat containing antisense to TP53
  zinc finger and BTB domain containing 10
  zinc finger protein 346
  zinc finger protein 496

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.