RCHY1, ring finger and CHY zinc finger domain containing 1

RCHY1, ring finger and CHY zinc finger domain containing 1

• The protein encoded by this gene has ubiquitin ligase activity. It mediates E3-dependent ubiquitination and proteasomal degradation of target proteins, including tumor protein 53, histone deacetylase 1, and cyclin-dependent kinase inhibitor 1B, thus regulating their levels and cell cycle progression. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2013]

• Gene Synonyms (RING finger and CHY zinc finger domain-containing protein 1, CH-rich interacting match with PLAG1, E3 ubiquitin-protein ligase Pirh2, RING finger protein 199, RING-type E3 ubiquitin transferase RCHY1, androgen-receptor N-terminal-interacting protein, p53-induced protein with a RING-H2 domain, ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase, zinc finger protein 363, zinc finger, CHY-type, ARNIP, CHIMP, PIRH2, PRO1996, RNF199, ZCHY, ZNF363,)
• NCBI Gene ID: 25898
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q96PM5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ring finger and CHY zinc finger domain containing 1 interacts with:

• ADAMTS like 4
  androgen induced 1
  angiopoietin like 8
  chromodomain helicase DNA binding protein 8
  COP1 E3 ubiquitin ligase
  defective in cullin neddylation 1 domain containing 5
  fatty acid desaturase 6
  golgin, RAB6 interacting
  keratin associated protein 9-2
  LIM zinc finger domain containing 2
  nemo like kinase
  NKD inhibitor of WNT signaling pathway 2
  notch 2 N-terminal like A
  Rab interacting lysosomal protein
  ring finger and CHY zinc finger domain containing 1
  RNA binding motif protein 38
  semaphorin 4C
  SERTA domain containing 1
  SRP receptor subunit beta
  TNFAIP3 interacting protein 2
  transmembrane BAX inhibitor motif containing 1
  transmembrane protein 14C
  transmembrane protein 184A
  tripartite motif containing 8
  ubiquitin associated and SH3 domain containing B
  ubiquitin conjugating enzyme E2 D4 (putative)
  ubiquitin specific peptidase 28
  WD repeat domain 74
  zinc finger protein 160

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.