SOCS6, suppressor of cytokine signaling 6

SOCS6, suppressor of cytokine signaling 6

• The protein encoded by this gene contains a SH2 domain and a CIS homolog domain. The protein thus belongs to the cytokine-induced STAT inhibitor (CIS), also known as suppressor of cytokine signaling (SOCS) or STAT-induced STAT inhibitor (SSI), protein family. CIS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by GM-CSF and EPO in hematopoietic cells. A high expression level of this gene was found in factor-independent chronic myelogenous leukemia (CML) and erythroleukemia (HEL) cell lines. [provided by RefSeq, Jul 2008]

• Gene Synonyms (suppressor of cytokine signaling 6, STAT induced STAT inhibitor-4, cytokine-inducible SH2 protein 4, suppressor of cytokine signaling 4, CIS-4, CIS4, HSPC060, SOCS-4, SOCS-6, SOCS4, SSI4, STAI4, STATI4,)
• NCBI Gene ID: 9306
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O14544
  UNIPROT ID#>>A0A024R379
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

suppressor of cytokine signaling 6 interacts with:

• actin related protein 3
  adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
  AFG3 like matrix AAA peptidase subunit 2
  ariadne RBR E3 ubiquitin protein ligase 2
  ataxin 10
  autophagy and beclin 1 regulator 1
  CDK5 regulatory subunit associated protein 2
  chromosome 1 open reading frame 109
  cytokine dependent hematopoietic cell linker
  defective in cullin neddylation 1 domain containing 1
  defective in cullin neddylation 1 domain containing 5
  DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
  DnaJ heat shock protein family (Hsp40) member C11
  enoyl-CoA delta isomerase 2
  FA complementation group I
  family with sequence similarity 83 member H
  F-box protein 11
  F-box protein 21
  fibroblast growth factor receptor substrate 3
  HCLS1 associated protein X-1
  HIG1 hypoxia inducible domain family member 1A
  inorganic pyrophosphatase 2
  isoleucyl-tRNA synthetase 2, mitochondrial
  KIAA0232
  LAS1 like ribosome biogenesis factor
  ligand of numb-protein X 1
  lysine demethylase 1A
  lysophosphatidylcholine acyltransferase 1
  matrix AAA peptidase interacting protein 1
  microtubule associated serine/threonine kinase like
  PDZ and LIM domain 5
  PGAM family member 5, mitochondrial serine/threonine protein phosphatase
  RANBP2-type and C3HC4-type zinc finger containing 1
  REST corepressor 1
  REST corepressor 3
  salvador family WW domain containing protein 1
  secretory carrier membrane protein 1
  secretory carrier membrane protein 3
  SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
  SID1 transmembrane family, member 2
  SMAD specific E3 ubiquitin protein ligase 2
  stromal cell derived factor 4
  testin LIM domain protein
  translocase of inner mitochondrial membrane 13
  translocase of inner mitochondrial membrane 50
  tubulin beta 4B class IVb
  tubulin delta 1
  tubulin gamma complex associated protein 2
  tubulin tyrosine ligase like 12
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  ubiquilin 1
  WD and tetratricopeptide repeats 1
  WD repeat domain 20
  WD repeat domain 48
  WD repeat domain 89
  zinc finger MIZ-type containing 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.