SPRY2, sprouty RTK signaling antagonist 2

SPRY2, sprouty RTK signaling antagonist 2

• This gene encodes a protein belonging to the sprouty family. The encoded protein contains a carboxyl-terminal cysteine-rich domain essential for the inhibitory activity on receptor tyrosine kinase signaling proteins and is required for growth factor stimulated translocation of the protein to membrane ruffles. In primary dermal endothelial cells this gene is transiently upregulated in response to fibroblast growth factor two. This protein is indirectly involved in the non-cell autonomous inhibitory effect on fibroblast growth factor two signaling. The protein interacts with Cas-Br-M (murine) ectropic retroviral transforming sequence, and can function as a bimodal regulator of epidermal growth factor receptor/mitogen-activated protein kinase signaling. This protein may play a role in alveoli branching during lung development as shown by a similar mouse protein. [provided by RefSeq, Jul 2008]

• Gene Synonyms (IGAN3, hSPRY2, protein sprouty homolog 2,)
• NCBI Gene ID: 10253
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O43597
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

sprouty RTK signaling antagonist 2 interacts with:

• ADAMTS like 4
  ATR interacting protein
  calcium binding protein 39
  catenin alpha 3
  cation channel sperm associated 1
  Cbl proto-oncogene C
  egl-9 family hypoxia inducible factor 1
  egl-9 family hypoxia inducible factor 2
  egl-9 family hypoxia inducible factor 3
  family with sequence similarity 219 member A
  Fas apoptotic inhibitory molecule
  F-box protein 7
  fibroblast growth factor receptor substrate 2
  fibroblast growth factor receptor substrate 3
  heterogeneous nuclear ribonucleoprotein L like
  HEXIM P-TEFb complex subunit 2
  homeobox A1
  hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7
  intersectin 1 (SH3 domain protein 1A)
  keratin associated protein 10-1
  keratin associated protein 10-11
  keratin associated protein 10-3
  keratin associated protein 10-5
  keratin associated protein 10-8
  keratin associated protein 10-9
  keratin associated protein 4-11
  keratin associated protein 4-12
  keratin associated protein 4-7
  keratin associated protein 5-6
  keratin associated protein 9-2
  keratin associated protein 9-4
  late cornified envelope 1A
  late cornified envelope 1B
  late cornified envelope 1C
  late cornified envelope 1F
  late cornified envelope 2D
  late cornified envelope 3C
  late cornified envelope 3E
  late cornified envelope 4A
  LON peptidase N-terminal domain and ring finger 1
  lysine demethylase 1A
  Mab-21 domain containing 2
  midline 2
  mitogen-activated protein kinase binding protein 1
  protein kinase C and casein kinase substrate in neurons 3
  protein tyrosine phosphatase, non-receptor type 11
  replication termination factor 2
  ring finger protein 123
  semaphorin 5B
  SH3 domain containing kinase binding protein 1
  shiftless antiviral inhibitor of ribosomal frameshifting
  sprouty RTK signaling antagonist 2
  sprouty RTK signaling antagonist 4
  tensin 2
  testin LIM domain protein
  thioredoxin domain containing 5
  transmembrane protein 14B
  tripartite motif-containing 51
  ubiquitin associated and SH3 domain containing A
  ubiquitin associated and SH3 domain containing B
  ubiquitin conjugating enzyme E2 E3
  ubiquitin protein ligase E3 component n-recognin 1
  ubiquitin specific peptidase 20
  vacuolar protein sorting 25 homolog
  vacuolar protein sorting 36 homolog
  VANGL planar cell polarity protein 1
  VANGL planar cell polarity protein 2
  zinc finger DHHC-type palmitoyltransferase 17
  zinc finger protein 266
  zinc finger protein 417
  zinc finger protein 587

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.