SPRY4, sprouty RTK signaling antagonist 4

SPRY4, sprouty RTK signaling antagonist 4

• This gene encodes a member of a family of cysteine- and proline-rich proteins. The encoded protein is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. Activity of this protein impairs the formation of active GTP-RAS. Nucleotide variation in this gene has been associated with hypogonadotropic hypogonadism 17 with or without anosmia. Alternative splicing results in a multiple transcript variants. [provided by RefSeq, Jun 2014]

• Gene Synonyms (protein sprouty homolog 4, sprouty homolog 4, HH17,)
• NCBI Gene ID: 81848
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9C004
  UNIPROT ID#>>A0A0C4DFS6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

sprouty RTK signaling antagonist 4 interacts with:

• kelch like family member 38
  keratin associated protein 5-11
  ORMDL sphingolipid biosynthesis regulator 3
  sprouty RTK signaling antagonist 4
  transmembrane protein 17

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.