MAPKBP1, mitogen-activated protein kinase binding protein 1

MAPKBP1, mitogen-activated protein kinase binding protein 1

• This gene encodes a scaffold protein that regulates the JNK (c-Jun N-terminal kinase) and NOD2 (nucleotide-binding oligomerization domain-containing protein 2) signaling pathways. The encoded protein interacts with another related JNK pathway scaffold protein, WDR62, via a conserved dimerization domain, and enhances JNK signaling. This protein may play a role in bacterial immunity by binding to the NOD2 receptor and negatively regulating downstream antibacterial and pro-inflammatory signaling. Mutations in this gene that impair cellular localization of the encoded protein cause a form of nephronophthisis, an autosomal-recessive kidney disorder, in human patients. [provided by RefSeq, May 2017]

• Gene Synonyms (JNKBP-1, JNKBP1, NPHP20, mitogen-activated protein kinase-binding protein 1, JNK-binding protein 1,)
• NCBI Gene ID: 23005
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O60336
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

mitogen-activated protein kinase binding protein 1 interacts with:

• ADAMTS like 4
  ALG13 UDP-N-acetylglucosaminyltransferase subunit
  aprataxin
  centrosomal protein 170
  CTD small phosphatase 1
  cysteine rich tail 1
  keratin 40
  keratin associated protein 10-1
  keratin associated protein 10-3
  keratin associated protein 10-7
  keratin associated protein 10-8
  keratin associated protein 10-9
  keratin associated protein 1-1
  keratin associated protein 12-3
  keratin associated protein 1-3
  keratin associated protein 13-1
  keratin associated protein 26-1
  keratin associated protein 3-1
  keratin associated protein 3-2
  keratin associated protein 4-12
  keratin associated protein 5-6
  keratin associated protein 5-7
  keratin associated protein 6-3
  keratin associated protein 9-2
  keratin associated protein 9-3
  keratin associated protein 9-4
  keratinocyte proline rich protein
  methyltransferase like 15
  NBPF member 19
  notch 2 N-terminal like A
  phospholipid scramblase 3
  protein phosphatase 4 regulatory subunit 3A
  tektin 5
  testis expressed 11
  tripartite motif containing 42
  WD repeat domain 62
  yippee like 5
  zinc finger protein 34

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.