UBE2L3, ubiquitin conjugating enzyme E2 L3

UBE2L3, ubiquitin conjugating enzyme E2 L3

• The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is demonstrated to participate in the ubiquitination of p53, c-Fos, and the NF-kB precursor p105 in vitro. Several alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]

• Gene Synonyms (ubiquitin-conjugating enzyme E2 L3, E2 ubiquitin-conjugating enzyme L3, ubiquitin carrier protein L3, ubiquitin conjugating enzyme E2L 3, ubiquitin-conjugating enzyme E2-F1, ubiquitin-conjugating enzyme UBCH7, ubiquitin-protein ligase L3, E2-F1, L-UBC, UBCH7, UbcM4,)
• NCBI Gene ID: 7332
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P68036
  UNIPROT ID#>>A0A024R1A4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ubiquitin conjugating enzyme E2 L3 interacts with:

• AAR2 splicing factor
  activation induced cytidine deaminase
  adenosylhomocysteinase like 1
  ankyrin repeat and IBR domain containing 1
  apoptosis resistant E3 ubiquitin protein ligase 1
  ariadne RBR E3 ubiquitin protein ligase 1
  ariadne RBR E3 ubiquitin protein ligase 2
  BAG cochaperone 3
  BRCA1 associated protein
  Cbl proto-oncogene C
  cullin 9
  cyclin B1 interacting protein 1
  DAZ associated protein 1
  deltex E3 ubiquitin ligase 3
  dynamin 1 like
  elongation factor Tu GTP binding domain containing 2
  eukaryotic translation initiation factor 4E family member 2
  F-box protein 2
  HECT and RLD domain containing E3 ubiquitin protein ligase 2
  HECT and RLD domain containing E3 ubiquitin protein ligase 3
  HECT and RLD domain containing E3 ubiquitin protein ligase 4
  HECT and RLD domain containing E3 ubiquitin protein ligase family member 1
  HECT and RLD domain containing E3 ubiquitin protein ligase family member 6
  HECT domain and ankyrin repeat containing E3 ubiquitin protein ligase 1
  HECT domain E3 ubiquitin protein ligase 1
  HECT domain E3 ubiquitin protein ligase 2
  HECT domain E3 ubiquitin protein ligase 4
  HECT, C2 and WW domain containing E3 ubiquitin protein ligase 1
  HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  heme binding protein 1
  interferon regulatory factor 2 binding protein 1
  itchy E3 ubiquitin protein ligase
  itchy, E3 ubiquitin protein ligase
  kinase suppressor of ras 1
  listerin E3 ubiquitin protein ligase 1
  makorin ring finger protein 3
  metabolism of cobalamin associated C
  mex-3 RNA binding family member A
  mex-3 RNA binding family member C
  microtubule associated protein 1 light chain 3 beta
  mitochondrial E3 ubiquitin protein ligase 1
  mitochondrial ribosomal protein L53
  musashi RNA binding protein 2
  MYC binding protein 2
  Nedd4 family interacting protein 1
  NEDD4 like E3 ubiquitin protein ligase
  neural precursor cell expressed, developmentally down-regulated 4
  neural precursor cell expressed, developmentally down-regulated gene 4-like
  nuclear receptor coactivator 1
  OTU deubiquitinase, ubiquitin aldehyde binding 1
  peptidyl-tRNA hydrolase domain containing 1
  PIH1 domain containing 1
  pirin
  pleckstrin homology domain containing A4
  praja ring finger ubiquitin ligase 1
  protein inhibitor of activated STAT 1
  protein inhibitor of activated STAT 2
  RAB10, member RAS oncogene family
  RANBP2-type and C3HC4-type zinc finger containing 1
  RecQ like helicase 4
  replication termination factor 2
  ring finger and CCCH-type domains 1
  ring finger protein 103
  ring finger protein 11
  ring finger protein 113B
  ring finger protein 114
  ring finger protein 125
  ring finger protein 14
  ring finger protein 144A
  ring finger protein 144B
  ring finger protein 150
  ring finger protein 168
  ring finger protein 170
  ring finger protein 182
  ring finger protein 19A, RBR E3 ubiquitin protein ligase
  ring finger protein 19B
  ring finger protein 20
  ring finger protein 213
  ring finger protein 216
  ring finger protein 220
  ring finger protein 31
  ring finger protein 7
  ring-box 1
  SMAD specific E3 ubiquitin protein ligase 1
  SMAD specific E3 ubiquitin protein ligase 2
  sorting nexin 12
  sorting nexin 3
  speckle type BTB/POZ protein
  splicing factor 1
  SRP receptor subunit beta
  STIP1 homology and U-box containing protein 1
  SURP and G-patch domain containing 1
  thyroid hormone receptor interactor 12
  TNF receptor associated factor 7
  TP53 induced glycolysis regulatory phosphatase
  transformation related protein 53
  translin associated factor X interacting protein 1
  tripartite motif containing 25
  tripartite motif containing 28
  tripartite motif containing 31
  tripartite motif containing 39
  tripartite motif containing 55
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  U box domain containing 5
  ubiquitin associated and SH3 domain containing A
  ubiquitin conjugating enzyme E2 L3
  ubiquitin conjugating enzyme E2 V2
  ubiquitin C-terminal hydrolase L3
  ubiquitin fold modifier 1
  ubiquitin like modifier activating enzyme 5
  ubiquitin like modifier activating enzyme 6
  ubiquitin protein ligase E3 component n-recognin 4
  ubiquitin protein ligase E3 component n-recognin 5
  ubiquitin protein ligase E3A
  ubiquitin protein ligase E3C
  ubiquitin specific peptidase 26
  ubiquitin specific peptidase 34
  ubiquitin specific peptidase 9 X-linked
  ubiquitination factor E4B
  U-box domain containing 5
  UBX domain protein 1
  UBX domain protein 7
  voltage dependent anion channel 2
  VPS11 core subunit of CORVET and HOPS complexes
  WD repeat domain, phosphoinositide interacting 2
  WW domain containing E3 ubiquitin protein ligase 1
  WW domain containing E3 ubiquitin protein ligase 2
  Yes1 associated transcriptional regulator
  zinc finger protein 598, E3 ubiquitin ligase
  ZPR1 zinc finger

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.