TIGAR, TP53 induced glycolysis regulatory phosphatase

TIGAR, TP53 induced glycolysis regulatory phosphatase

• This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq, Jul 2008]

• Gene Synonyms (C12orf5, FR2BP, fructose-2,6-bisphosphatase TIGAR, TP53-induced glycolysis and apoptosis regulator, fructose-2,6-bisphosphate 2-phosphatase, probable fructose-2,6-bisphosphatase TIGAR, transactivated by NS3TP2 protein,)
• NCBI Gene ID: 57103
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9NQ88
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

TP53 induced glycolysis regulatory phosphatase interacts with:

• LYR motif containing 2
  methionine sulfoxide reductase B3
  SHANK associated RH domain interactor

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.