DNM1L, dynamin 1 like

DNM1L, dynamin 1 like

• This gene encodes a member of the dynamin superfamily of GTPases. The encoded protein mediates mitochondrial and peroxisomal division, and is involved in developmentally regulated apoptosis and programmed necrosis. Dysfunction of this gene is implicated in several neurological disorders, including Alzheimer's disease. Mutations in this gene are associated with the autosomal dominant disorder, encephalopathy, lethal, due to defective mitochondrial and peroxisomal fission (EMPF). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]

• Gene Synonyms (dynamin-1-like protein, Dnm1p/Vps1p-like protein, dynamin family member proline-rich carboxyl-terminal domain less, dynamin-like protein 4, dynamin-like protein IV, dynamin-related protein 1, DLP1, DRP1, DVLP, DYMPLE, EMPF, EMPF1, HDYNIV, OPA5,)
• NCBI Gene ID: 10059
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B4DYR6
  UNIPROT ID#>>O00429
  UNIPROT ID#>>G8JLD5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

dynamin 1 like interacts with:

• actin related protein 1A
  activator of HSP90 ATPase activity 1
  ADP ribosylation factor interacting protein 1
  apoptotic chromatin condensation inducer 1
  carbonic anhydrase 14
  cell division cycle 37, HSP90 cochaperone
  cell division cycle associated 5
  chaperonin containing TCP1 subunit 2
  chaperonin containing TCP1 subunit 7
  chaperonin containing TCP1 subunit 8
  COP9 signalosome subunit 5
  copine 2
  creatine kinase, mitochondrial 1A
  C-type lectin domain containing 14A
  cysteine and histidine rich 1
  cytochrome c oxidase assembly factor COX14
  dermcidin
  dual specificity phosphatase 23
  dynactin subunit 2
  dynamin 1 like
  dynein axonemal assembly factor 2
  fission, mitochondrial 1
  fizzy and cell division cycle 20 related 1
  glucosidase II alpha subunit
  HCLS1 associated protein X-1
  heat shock protein family H (Hsp110) member 1
  heterogeneous nuclear ribonucleoprotein A1 like 2
  jumonji domain containing 6, arginine demethylase and lysine hydroxylase
  kinesin family member 19A
  leucine rich repeat kinase 2
  leucyl-tRNA synthetase 1
  magnesium dependent phosphatase 1
  membrane associated ring-CH-type finger 5
  mitochondrial E3 ubiquitin protein ligase 1
  mitochondrial elongation factor 1
  mitochondrial elongation factor 2
  mitochondrial fission factor
  myosin light chain 12A
  NHL repeat containing 2
  niban apoptosis regulator 2
  NIMA (never in mitosis gene a)-related expressed kinase 2
  nuclear FMR1 interacting protein 1
  Parkinsonism associated deglycase
  peptidyl-tRNA hydrolase 2
  peroxisomal biogenesis factor 11 gamma
  phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
  plasminogen receptor with a C-terminal lysine
  pleckstrin homology domain containing A4
  poly(A) binding protein cytoplasmic 1
  potassium channel tetramerization domain containing 12
  proteasome assembly chaperone 3
  protein disulfide isomerase family A member 6
  PTEN induced kinase 1
  RAB32, member RAS oncogene family
  RBMX like 2
  RNA binding protein with serine rich domain 1
  RNA transcription, translation and transport factor
  RuvB like AAA ATPase 2
  SEC24 homolog A, COPII coat complex component
  secretogranin III
  SERPINE1 mRNA binding protein 1
  sideroflexin 1
  Sin3A associated protein 18
  sirtuin 3
  SNW domain containing 1
  splicing factor 3b subunit 6
  stress induced phosphoprotein 1
  SUB1 regulator of transcription
  SUMO specific peptidase 3
  TBC1 domain family member 15
  testin LIM domain protein
  translocase of inner mitochondrial membrane 13
  translocase of outer mitochondrial membrane 22
  tripartite motif containing 28
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  unk zinc finger
  WD repeat domain 5
  WW domain containing oxidoreductase
  zinc finger and BTB domain containing 7A

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.