SIRT3, sirtuin 3

SIRT3, sirtuin 3

• SIRT3 encodes a member of the sirtuin family of class III histone deacetylases, homologs to the yeast Sir2 protein. The encoded protein is found exclusively in mitochondria, where it can eliminate reactive oxygen species, inhibit apoptosis, and prevent the formation of cancer cells. SIRT3 has far-reaching effects on nuclear gene expression, cancer, cardiovascular disease, neuroprotection, aging, and metabolic control. [provided by RefSeq, May 2019]

• Gene Synonyms (NAD-dependent protein deacetylase sirtuin-3, mitochondrial, NAD-dependent deacetylase sirtuin-3, mitochondrial, SIR2-like protein 3, mitochondrial nicotinamide adenine dinucleotide-dependent deacetylase, regulatory protein SIR2 homolog 3, silent mating type information regulation 2, S.cerevisiae, homolog 3, sir2-like 3, sirtuin type 3, SIR2L3,)
• NCBI Gene ID: 23410
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9NTG7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

sirtuin 3 interacts with:

• acyl-CoA dehydrogenase family member 9
  cardiomyopathy associated 5
  ETHE1 persulfide dioxygenase
  hydroxysteroid dehydrogenase like 2
  LSM family member 14B
  methionyl aminopeptidase type 1D, mitochondrial
  mitochondrial ribosomal protein L42
  mitochondrial ribosome associated GTPase 2
  NADH:ubiquinone oxidoreductase core subunit S7
  oxidoreductase like domain containing 1
  post-GPI attachment to proteins inositol deacylase 1
  pyruvate dehyrogenase phosphatase catalytic subunit 1
  regenerating family member 4
  replication timing regulatory factor 1
  Rho guanine nucleotide exchange factor 26
  transmembrane protein 25
  tripartite motif containing 43
  ybeY metalloendoribonuclease

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.