MYL12A, myosin light chain 12A

MYL12A, myosin light chain 12A

• This gene encodes a nonsarcomeric myosin regulatory light chain. This protein is activated by phosphorylation and regulates smooth muscle and non-muscle cell contraction. This protein may also be involved in DNA damage repair by sequestering the transcriptional regulator apoptosis-antagonizing transcription factor (AATF)/Che-1 which functions as a repressor of p53-driven apoptosis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8.[provided by RefSeq, Dec 2014]

• Gene Synonyms (HEL-S-24, MLC-2B, MLCB, MRCL3, MRLC3, MYL2B, myosin regulatory light chain 12A, epididymis secretory protein Li 24, myosin RLC, myosin regulatory light chain 2, nonsarcomeric, myosin regulatory light chain 3, myosin regulatory light chain MRLC3, myosin, light chain 12A, regulatory, non-sarcomeric, myosin, light polypeptide, regulatory, non-sarcomeric (20kD),)
• NCBI Gene ID: 10627
• Species: Homo sapiens (Human)
• UNIPROT ID#>>J3QRS3
  UNIPROT ID#>>O14950
  UNIPROT ID#>>P19105
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

myosin light chain 12A interacts with:

• anillin actin binding protein
  cell division cycle 73
  component of oligomeric golgi complex 3
  huntingtin interacting protein K
  La ribonucleoprotein 7, transcriptional regulator
  lectin, galactoside-binding, soluble, 3 binding protein
  methylphosphate capping enzyme
  mitochondrial ribosomal protein S21
  myosin heavy chain 14
  myosin IC
  myosin XIX
  myosin XVIIIA
  myosin, heavy polypeptide 10, non-muscle
  myosin, heavy polypeptide 9, non-muscle
  Parkinsonism associated deglycase
  PAX interacting protein 1
  PIH1 domain containing 1
  potassium channel tetramerization domain containing 15
  prohibitin 2
  RAB, member RAS oncogene family like 6
  Rac GTPase-activating protein 1
  RAD18 E3 ubiquitin protein ligase
  ring finger protein 123
  SUMO specific peptidase 2
  suppressor of variegation 3-9 homolog 2
  tet methylcytosine dioxygenase 2
  translocase of outer mitochondrial membrane 22
  vir like m6A methyltransferase associated
  WD repeat domain 77
  zinc finger protein 746

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.