YAP1, Yes1 associated transcriptional regulator

YAP1, Yes1 associated transcriptional regulator

• This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013]

• Gene Synonyms (COB1, YAP, YAP2, YAP65, YKI, transcriptional coactivator YAP1, 65 kDa Yes-associated protein, Yes associated protein 1, protein yorkie homolog, yes-associated protein 1, yes-associated protein 2, yes-associated protein YAP65 homolog, yorkie homolog,)
• NCBI Gene ID: 10413
• Species: Homo sapiens (Human)
• UNIPROT ID#>>K0KVU2
  UNIPROT ID#>>Q86T74
  UNIPROT ID#>>A0A024R3E4
  UNIPROT ID#>>P46937
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Yes1 associated transcriptional regulator interacts with:

• 1-acylglycerol-3-phosphate O-acyltransferase 1
  5'-3' exoribonuclease 2
  actin beta like 2
  acyl-CoA dehydrogenase family member 9
  adenosylhomocysteinase like 1
  ADP ribosylation factor interacting protein 1
  AHNAK nucleoprotein
  ajuba LIM protein
  angiomotin
  angiomotin
  angiomotin like 1
  angiomotin like 2
  apoptotic chromatin condensation inducer 1
  arrestin domain containing 1
  arrestin domain containing 3
  ATP synthase inhibitory factor subunit 1
  ATPase family AAA domain containing 3A
  ATPase family AAA domain containing 3B
  AT-rich interaction domain 1B
  AT-rich interaction domain 3B
  BCL9 like
  carboxypeptidase vitellogenic like
  caveolae associated protein 1
  chaperonin containing TCP1 subunit 2
  chaperonin containing TCP1 subunit 4
  chaperonin containing TCP1 subunit 5
  chaperonin containing TCP1 subunit 8
  cleavage and polyadenylation specific factor 6
  cleavage and polyadenylation specific factor 7
  coiled-coil domain containing 120
  coiled-coil domain containing 25
  coiled-coil domain containing 85C
  collagen type XVIII alpha 1 chain
  copine 2
  coronin 1C
  cullin associated and neddylation dissociated 1
  cysteine and tyrosine rich 1
  cytokine induced apoptosis inhibitor 1
  cytoplasmic FMR1 interacting protein 1
  DEAD-box helicase 17
  DnaJ heat shock protein family (Hsp40) member C10
  egl-9 family hypoxia inducible factor 3
  ENAH actin regulator
  endoplasmic reticulum protein 44
  eukaryotic translation initiation factor 3 subunit L
  family with sequence similarity 120A
  family with sequence similarity 133 member B
  family with sequence similarity 189 member B
  F-box and WD repeat domain containing 11
  F-box and WD repeat domain containing 7
  filaggrin family member 2
  G protein subunit alpha 13
  G protein subunit beta 4
  G protein subunit gamma 12
  GPN-loop GTPase 1
  GPN-loop GTPase 3
  H2A clustered histone 1
  heat shock protein family A (Hsp70) member 4 like
  heat shock protein family H (Hsp110) member 1
  heterogeneous nuclear ribonucleoprotein A1 like 2
  heterogeneous nuclear ribonucleoprotein C like 1
  heterogeneous nuclear ribonucleoprotein U like 1
  hornerin
  hypoxia up-regulated 1
  importin 7
  inner membrane mitochondrial protein
  itchy E3 ubiquitin protein ligase
  Josephin domain containing 2
  Jupiter microtubule associated homolog 2
  keratin 25
  keratin 76
  keratin 79
  large tumor suppressor kinase 2
  late endosomal/lysosomal adaptor, MAPK and MTOR activator 1
  leucine rich repeat containing 59
  leucine zipper tumor suppressor 2
  lin-7 homolog C (C. elegans)
  lin-7 homolog C, crumbs cell polarity complex component
  membrane palmitoylated protein 5
  minichromosome maintenance complex binding protein
  myosin heavy chain 14
  myosin IIIB
  myosin light chain 12A
  myosin light chain 6B
  myosin phosphatase Rho interacting protein
  NDRG family member 4
  Nedd4 family interacting protein 2
  NFKB repressing factor
  nuclear distribution C, dynein complex regulator
  nuclear factor of activated T cells 5
  nuclear RNA export factor 1
  nudix hydrolase 5
  OTU deubiquitinase 1
  OTU deubiquitinase 7B
  OTU deubiquitinase, ubiquitin aldehyde binding 2
  par-3 family cell polarity regulator
  PDZ and LIM domain 5
  peroxiredoxin 3
  PGAM family member 5, mitochondrial serine/threonine protein phosphatase
  phosphoglycerate dehydrogenase
  phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase
  poly(A) binding protein cytoplasmic 1
  poly(A) polymerase alpha
  POTE ankyrin domain family member E
  POTE ankyrin domain family member F
  POTE ankyrin domain family member I
  POTE ankyrin domain family member J
  pre-mRNA processing factor 8
  prohibitin 2
  proline rich and Gla domain 4
  protein arginine methyltransferase 5
  protein tyrosine phosphatase non-receptor type 21
  PTEN induced kinase 1
  Rap guanine nucleotide exchange factor 6
  Ras association domain family member 8
  reticulon 4
  retinoic acid induced 14
  ribosomal protein L13a
  ribosomal protein L36
  ribosomal RNA processing 1B
  RTF1 homolog, Paf1/RNA polymerase II complex component
  Sad1 and UNC84 domain containing 2
  salvador family WW domain containing protein 1
  serine/arginine repetitive matrix 2
  sideroflexin 1
  signal induced proliferation associated 1 like 3
  SMAD family member 7
  small nuclear ribonucleoprotein U5 subunit 200
  solute carrier family 25 member 31
  spindlin interactor and repressor of chromatin binding
  splicing factor 3b subunit 3
  SPT16 homolog, facilitates chromatin remodeling subunit
  staphylococcal nuclease and tudor domain containing 1
  stress induced phosphoprotein 1
  synaptotagmin binding cytoplasmic RNA interacting protein
  TANK binding kinase 1
  tetratricopeptide repeat domain 9C
  TGF-beta activated kinase 1 (MAP3K7) binding protein 1
  TGF-beta activated kinase 1 (MAP3K7) binding protein 3
  THUMP domain containing 1
  toll interacting protein
  transmembrane protein 109
  TRIO and F-actin binding protein
  tropomodulin 3
  TSR1 ribosome maturation factor
  TUB like protein 4
  tubulin alpha 1c
  tubulin alpha 3e
  tubulin alpha 4b
  tubulin alpha 8
  tubulin alpha like 3
  tubulin beta 1 class VI
  tubulin beta 6 class V
  tubulin beta 8 class VIII
  tubulin beta 8B
  tubulin beta class I
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  ubiquilin 1
  ubiquilin 2
  ubiquitin conjugating enzyme E2 C
  ubiquitin domain containing 1
  ubiquitin fold modifier 1
  ubiquitin specific peptidase 47
  UBX domain protein 7
  unk zinc finger
  uveal autoantigen with coiled-coil domains and ankyrin repeats
  vacuolar protein sorting 25 homolog
  WD repeat domain 5
  WD repeat domain 6
  WW and C2 domain containing 1
  WW and C2 domain containing 2
  WW domain binding protein 1
  WW domain binding protein 1
  WW domain binding protein 2
  WW domain binding protein 2
  WWC family member 3
  Yes1 associated transcriptional regulator
  YOD1 deubiquitinase
  zinc finger FYVE-type containing 19

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.