PRMT5, protein arginine methyltransferase 5

PRMT5, protein arginine methyltransferase 5

• This gene encodes an enzyme that belongs to the methyltransferase family. The encoded protein catalyzes the transfer of methyl groups to the amino acid arginine, in target proteins that include histones, transcriptional elongation factors and the tumor suppressor p53. This gene plays a role in several cellular processes, including transcriptional regulation, and the assembly of small nuclear ribonucleoproteins. A pseudogene of this gene has been defined on chromosome 4. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

• Gene Synonyms (HRMT1L5, HSL7, IBP72, JBP1, SKB1, SKB1Hs, protein arginine N-methyltransferase 5, 72 kDa ICln-binding protein, HMT1 hnRNP methyltransferase-like 5, SKB1 homolog, histone-arginine N-methyltransferase PRMT5, jak-binding protein 1, shk1 kinase-binding protein 1 homolog,)
• NCBI Gene ID: 10419
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O14744
  UNIPROT ID#>>B4DV00
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

protein arginine methyltransferase 5 interacts with:

• activator of HSP90 ATPase activity 1
  ajuba LIM protein
  alkB homolog 3, alpha-ketoglutarate dependent dioxygenase
  anterior gradient 2, protein disulphide isomerase family member
  arginine and glutamate rich 1
  arginine and serine rich protein 1
  argonaute RISC catalytic component 3
  argonaute RISC component 4
  ariadne RBR E3 ubiquitin protein ligase 2
  AT-rich interaction domain 1B
  autophagy related 16 like 1
  BCL2 like 14
  bromodomain containing 4
  cap methyltransferase 1
  catenin beta like 1
  cell cycle and apoptosis regulator 2
  cell division cycle 37, HSP90 cochaperone
  chromatin target of PRMT1
  chromodomain Y like 2
  chromosome 1 open reading frame 109
  coactivator associated arginine methyltransferase 1
  coiled-coil domain containing 33
  coordinator of PRMT5 and differentiation stimulator
  COP9 signalosome subunit 4
  COP9 signalosome subunit 7A
  cyclin dependent kinase 19
  DDB1 and CUL4 associated factor 4 like 2
  DDB1 and CUL4 associated factor 8
  dual specificity phosphatase 14
  egl-9 family hypoxia inducible factor 3
  erythrocyte membrane protein band 4.1 like 3
  family with sequence similarity 76 member B
  F-box protein 25
  F-box protein 6
  fibrillarin
  forkhead box K1
  GAR1 ribonucleoprotein
  GLIS family zinc finger 3
  grainyhead like transcription factor 3
  GTP binding protein 2
  H3.5 histone
  H4 histone 16
  HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2
  heterogeneous nuclear ribonucleoprotein H1
  HEXIM P-TEFb complex subunit 1
  inhibitor of growth family member 5
  KH RNA binding domain containing, signal transduction associated 2
  KN motif and ankyrin repeat domains 2
  La ribonucleoprotein 7, transcriptional regulator
  lactate dehydrogenase A like 6B
  leucine rich repeats and WD repeat domain containing 1
  leukocyte receptor cluster member 8
  ligand of numb-protein X 1
  listerin E3 ubiquitin protein ligase 1
  LSM11, U7 small nuclear RNA associated
  LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
  LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated
  LUC7 like
  lysine demethylase 1A
  lysine demethylase 2B
  lysine demethylase 3A
  lysine demethylase 3B
  lysine demethylase 4C
  lysine demethylase 6B
  methyltransferase like 3
  microspherule protein 1
  mindbomb E3 ubiquitin protein ligase 1
  mitochondrial ribosomal protein L11
  Myb like, SWIRM and MPN domains 1
  myelin expression factor 2
  negative elongation factor complex member C/D
  NSFL1 cofactor
  N-terminal glutamine amidase 1
  NudC domain containing 2
  Obg like ATPase 1
  O-sialoglycoprotein endopeptidase
  PAX interacting protein 1
  peptidylprolyl isomerase E
  PHD finger protein 8
  phosphopantothenoylcysteine synthetase
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  PR domain containing 1, with ZNF domain
  pre-mRNA processing factor 38A
  programmed cell death 4
  protein arginine methyltransferase 5
  protein arginine methyltransferase 6
  PTEN induced kinase 1
  required for meiotic nuclear division 5 homolog A
  ribosomal RNA processing 12 homolog
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  ring finger protein 123
  RIO kinase 1
  RNA binding fox-1 homolog 1
  RNA binding fox-1 homolog 2
  RNA binding motif protein 23
  SHANK associated RH domain interactor
  SIN3 transcription regulator family member A
  sirtuin 6
  sirtuin 7
  SLU7 homolog, splicing factor
  SMAD specific E3 ubiquitin protein ligase 1
  sperm associated antigen 8
  spindle apparatus coiled-coil protein 1
  splicing factor 3a subunit 3
  strawberry notch homolog 1
  tribbles pseudokinase 3
  tubulointerstitial nephritis antigen like 1
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  ubiquitin conjugating enzyme E2 Q2
  ubiquitin like with PHD and ring finger domains 1
  vir like m6A methyltransferase associated
  WD repeat domain 5
  WD repeat domain 77
  WW domain containing E3 ubiquitin protein ligase 2
  WW domain containing oxidoreductase
  zinc finger containing ubiquitin peptidase 1
  zinc finger DHHC-type palmitoyltransferase 17
  zinc finger HIT-type containing 6
  zinc finger MYND-type containing 19
  zinc finger protein 326
  zinc finger protein 436
  zinc finger protein 598, E3 ubiquitin ligase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.