DUSP14, dual specificity phosphatase 14

DUSP14, dual specificity phosphatase 14

• Dual-specificity phosphatases (DUSPs) constitute a large heterogeneous subgroup of the type I cysteine-based protein-tyrosine phosphatase superfamily. DUSPs are characterized by their ability to dephosphorylate both tyrosine and serine/threonine residues. They have been implicated as major modulators of critical signaling pathways. DUSP14 contains the consensus DUSP C-terminal catalytic domain but lacks the N-terminal CH2 domain found in the MKP (mitogen-activated protein kinase phosphatase) class of DUSPs (see MIM 600714) (summary by Patterson et al., 2009 [PubMed 19228121]).[supplied by OMIM, Dec 2009]

• Gene Synonyms (dual specificity protein phosphatase 14, MAP kinase phosphatase 6, MKP-1-like protein tyrosine phosphatase, MKP-6, mitogen-activated protein kinase phosphatase 6, MKP-L, MKP6,)
• NCBI Gene ID: 11072
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q6FI36
  UNIPROT ID#>>O95147
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

dual specificity phosphatase 14 interacts with:

• acyl-CoA dehydrogenase family member 8
  cell cycle and apoptosis regulator 2
  chibby family member 2
  Coenzyme A synthase
  coiled-coil domain containing 173
  coiled-coil domain containing 51
  complexin 3
  DLG associated protein 3
  Era like 12S mitochondrial rRNA chaperone 1
  family with sequence similarity 120A
  family with sequence similarity 136 member A
  F-box and leucine rich repeat protein 4
  flavin adenine dinucleotide synthetase 1
  forkhead box P2
  GC-rich promoter binding protein 1
  HEAT repeat containing 1
  heterogeneous nuclear ribonucleoprotein A1 like 2
  heterogeneous nuclear ribonucleoprotein A3
  heterogeneous nuclear ribonucleoprotein L like
  heterogeneous nuclear ribonucleoprotein U like 2
  inositol-3-phosphate synthase 1
  interleukin 31 receptor A
  kinesin family member 3A
  laccase domain containing 1
  lemur tyrosine kinase 2
  ligand of numb-protein X 1
  lysophosphatidylcholine acyltransferase 4
  mitochondrial ribosomal protein L38
  mitochondrial ribosomal protein L39
  mitochondrial ribosomal protein S18B
  mitochondrial ribosomal protein S22
  mitochondrial ribosomal protein S35
  mitochondrial ribosomal protein S7
  NHL repeat containing 2
  nudix hydrolase 5
  olfactory receptor family 51 subfamily E member 2
  ornithine decarboxylase antizyme 3
  OTU deubiquitinase with linear linkage specificity
  P2Y receptor family member 8
  pyrin and HIN domain family member 1
  pyrroline-5-carboxylate reductase 2
  RAB11 family interacting protein 4
  RAS guanyl releasing protein 4
  Rho related BTB domain containing 2
  RNA binding motif protein X-linked
  SET domain bifurcated histone lysine methyltransferase 2
  shugoshin 2
  ST6 N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
  synaptotagmin 16
  tensin 2
  ubiquitin C-terminal hydrolase L5
  zinc finger protein 326

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.