LACC1, laccase domain containing 1

LACC1, laccase domain containing 1

• This gene encodes an oxidoreductase that promotes fatty-acid oxidation, with concomitant inflammasome activation, mitochondrial and NADPH-oxidase-dependent reactive oxygen species production, and bactericidal activity of macrophages. The encoded protein forms a complex with fatty acid synthase on peroxisomes and is thought to be modulated by peroxisome proliferator-activated receptor signaling events. Naturally occurring mutations in this gene are associated with inflammatory bowel disease, Behcet's disease, leprosy, ulcerative colitis, early-onset Crohn's disease, and systemic juvenile idiopathic arthritis. [provided by RefSeq, Apr 2017]

• Gene Synonyms (C13orf31, FAMIN, JUVAR, purine nucleoside phosphorylase LACC1, laccase domain-containing protein 1, S-methyl-5'-thioadenosine phosphorylase LACC1, adenosine deaminase LACC1, fatty acid metabolism-immunity nexus, guanosine phosphorylase LACC1, laccase (multicopper oxidoreductase) domain containing 1,)
• NCBI Gene ID: 144811
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8IV20
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

laccase domain containing 1 interacts with:

• autophagy related 9B
  calcium homeostasis modulator family member 4
  desmoglein 4
  H3.2 histone (putative)
  hephaestin like 1
  lysozyme g2
  PALM2 and AKAP2 fusion
  V-set and immunoglobulin domain containing 8

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.