SIPA1L3, signal induced proliferation associated 1 like 3

SIPA1L3, signal induced proliferation associated 1 like 3

• This gene belongs to the signal induced proliferation associated 1 family of genes, which encode GTPase-activating proteins specific for the GTP-binding protein Rap1. Rap1 has been implicated in regulation of cell adhesion, cell polarity, and organization of the cytoskeleton. Like other members of the family, the protein encoded by this gene contains RapGAP and PDZ domains. In addition, this protein contains a C-terminal leucine zipper domain. This gene is proposed to function in epithelial cell morphogenesis and establishment or maintenance of polarity. Consistently, expression of the protein in cell culture showed localization to cell-cell borders in apical regions, and downregulation of the gene in 3D Caco2 cell culture resulted in abnormal cell polarity and morphogenesis. Allelic variants of this gene have been associated with congenital cataracts in humans. [provided by RefSeq, Feb 2016]

• Gene Synonyms (CTRCT45, SPAL3, SPAR3, signal-induced proliferation-associated 1-like protein 3, SIPA1-like protein 3, SPA-1-like protein 3, spine-associated RapGAP 3,)
• NCBI Gene ID: 23094
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B2RWP0
  UNIPROT ID#>>O60292
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

signal induced proliferation associated 1 like 3 interacts with:

• BICD cargo adaptor 2
  calmodulin-like 3
  CDK5 regulatory subunit associated protein 2
  cell division cycle 26
  centrosomal protein 135
  centrosomal protein 72
  dynein cytoplasmic 1 light intermediate chain 1
  egl-9 family hypoxia inducible factor 3
  hook microtubule tethering protein 1
  hook microtubule tethering protein 3
  large tumor suppressor kinase 2
  leucine zipper tumor suppressor 2
  LIM domain and actin binding 1
  myosin XIX
  myosin XVIIIA
  myosin, heavy polypeptide 10, non-muscle
  ninein
  RAD18 E3 ubiquitin protein ligase
  RPGRIP1 like
  TNFAIP3 interacting protein 2
  torsin A interacting protein 1
  vir like m6A methyltransferase associated
  WD repeat domain 83

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.