UBE2E1, ubiquitin conjugating enzyme E2 E1

UBE2E1, ubiquitin conjugating enzyme E2 E1

• The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

• Gene Synonyms (ubiquitin-conjugating enzyme E2 E1, (E3-independent) E2 ubiquitin-conjugating enzyme E1, E2 ubiquitin-conjugating enzyme E1, ubiquitin carrier protein E1, ubiquitin conjugating enzyme E2E 1, ubiquitin-conjugating enzyme E2E 1 (UBC4/5 homolog, yeast), ubiquitin-conjugating enzyme E2E 1 (homologous to yeast UBC4/5), ubiquitin-protein ligase E1, UBCH6,)
• NCBI Gene ID: 7324
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P51965
  UNIPROT ID#>>A0A024R2K3
  UNIPROT ID#>>B7Z306
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ubiquitin conjugating enzyme E2 E1 interacts with:

• ariadne RBR E3 ubiquitin protein ligase 2
  ASXL transcriptional regulator 2
  baculoviral IAP repeat containing 7
  calcium dependent secretion activator 2
  checkpoint with forkhead and ring finger domains
  COBW domain containing 5
  CTR9 homolog, Paf1/RNA polymerase II complex component
  cullin 3
  DAZ interacting zinc finger protein 3
  deltex E3 ubiquitin ligase 3
  deltex E3 ubiquitin ligase 3L
  denticleless E3 ubiquitin protein ligase homolog
  DET1 and DDB1 associated 1
  DET1 partner of COP1 E3 ubiquitin ligase
  DNA polymerase lambda
  DNA polymerase mu
  F-box protein 2
  F-box protein 7
  H3 clustered histone 1
  H4 clustered histone 1
  histone deacetylase 6
  importin 11
  itchy E3 ubiquitin protein ligase
  jade family PHD finger 1
  LEO1 homolog, Paf1/RNA polymerase II complex component
  leucine rich repeat and sterile alpha motif containing 1
  macroH2A.1 histone
  mahogunin ring finger 1
  makorin ring finger protein 3
  membrane associated ring-CH-type finger 3
  membrane associated ring-CH-type finger 5
  membrane associated ring-CH-type finger 7
  methyl-CpG binding domain protein 5
  midline 2
  mitochondrial E3 ubiquitin protein ligase 1
  NEDD4 like E3 ubiquitin protein ligase
  neural precursor cell expressed, developmentally down-regulated gene 4-like
  NHL repeat containing E3 ubiquitin protein ligase 1
  OTU deubiquitinase, ubiquitin aldehyde binding 1
  PAF1 homolog, Paf1/RNA polymerase II complex component
  pleckstrin homology domain containing A4
  polycomb group ring finger 5
  recombination activating 1
  required for meiotic nuclear division 5 homolog B
  ring finger and WD repeat domain 3
  ring finger protein 10
  ring finger protein 103
  ring finger protein 11
  ring finger protein 111
  ring finger protein 112
  ring finger protein 114
  ring finger protein 115
  ring finger protein 115
  ring finger protein 122
  ring finger protein 128
  ring finger protein 13
  ring finger protein 130
  ring finger protein 14
  ring finger protein 150
  ring finger protein 152
  ring finger protein 165
  ring finger protein 166
  ring finger protein 167
  ring finger protein 168
  ring finger protein 169
  ring finger protein 181
  ring finger protein 185
  ring finger protein 20
  ring finger protein 25
  ring finger protein 26
  ring finger protein 31
  ring finger protein 40
  ring finger protein 43
  ring finger protein 8
  ring finger protein, LIM domain interacting
  salt inducible kinase 1
  STIP1 homology and U-box containing protein 1
  TOP1 binding arginine/serine rich protein, E3 ubiquitin ligase
  tribbles pseudokinase 1
  tribbles pseudokinase 2
  tripartite motif containing 11
  tripartite motif containing 17
  tripartite motif containing 2
  tripartite motif containing 28
  tripartite motif containing 29
  tripartite motif containing 3
  tripartite motif containing 32
  tripartite motif containing 33
  tripartite motif containing 38
  tripartite motif containing 39
  tripartite motif containing 45
  tripartite motif containing 50
  tripartite motif containing 69
  tripartite motif containing 7
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta
  ubiquitin associated and SH3 domain containing B
  ubiquitin conjugating enzyme E2 E1
  ubiquitin conjugating enzyme E2 G1
  ubiquitin conjugating enzyme E2 I
  ubiquitin fold modifier 1
  ubiquitin protein ligase E3 component n-recognin 7
  ubiquitin protein ligase E3A
  ubiquitin specific peptidase 7
  ubiquitin specific peptidase 8
  U-box domain containing 5
  UV stimulated scaffold protein A
  WW domain containing E3 ubiquitin protein ligase 2
  zinc and ring finger 1
  zinc and ring finger 2
  zinc and ring finger 4
  zinc finger protein 827

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.