HMGA2, high mobility group AT-hook 2

HMGA2, high mobility group AT-hook 2

• This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

• Gene Synonyms (high mobility group protein HMGI-C, HMGA2/KRT121P fusion, high-mobility group (nonhistone chromosomal) protein isoform I-C, BABL, HMGI-C, HMGIC, LIPO, SRS5, STQTL9,)
• NCBI Gene ID: 8091
• Species: Homo sapiens (Human)
• UNIPROT ID#>>F5H6H0
  UNIPROT ID#>>F5H2A4
  UNIPROT ID#>>P52926
  UNIPROT ID#>>Q1M183
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

high mobility group AT-hook 2 interacts with:

• H3 clustered histone 1
  obscurin like cytoskeletal adaptor 1
  PC4 and SFRS1 interacting protein 1
  polycomb group ring finger 1
  protein arginine methyltransferase 6
  protein inhibitor of activated STAT 3
  SUZ12 polycomb repressive complex 2 subunit
  synaptotagmin binding cytoplasmic RNA interacting protein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.