KLF4, Kruppel like factor 4

KLF4, Kruppel like factor 4

• This gene encodes a protein that belongs to the Kruppel family of transcription factors. The encoded zinc finger protein is required for normal development of the barrier function of skin. The encoded protein is thought to control the G1-to-S transition of the cell cycle following DNA damage by mediating the tumor suppressor gene p53. Mice lacking this gene have a normal appearance but lose weight rapidly, and die shortly after birth due to fluid evaporation resulting from compromised epidermal barrier function. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]

• Gene Synonyms (Krueppel-like factor 4, Kruppel-like factor 4 (gut), endothelial Kruppel-like zinc finger protein, epithelial zinc finger protein EZF, gut Kruppel-like factor, gut-enriched krueppel-like factor, EZF, GKLF,)
• NCBI Gene ID: 9314
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O43474
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Kruppel like factor 4 interacts with:

• BAALC binder of MAP3K1 and KLF4
  BCL2-associated athanogene 2
  F-box protein 22
  F-box protein 32
  F-box protein 7
  heat shock transcription factor 2 binding protein
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  histone deacetylase 5
  histone deacetylase 7
  lysine acetyltransferase 5
  methyl-CpG binding domain protein 2
  myosin XVB
  nuclear receptor interacting protein 3
  protein phosphatase 2, regulatory subunit B, delta
  SET domain containing 7, histone lysine methyltransferase
  spire type actin nucleation factor 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.