HDAC4, histone deacetylase 4

HDAC4, histone deacetylase 4

• Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. This protein does not bind DNA directly, but through transcription factors MEF2C and MEF2D. It seems to interact in a multiprotein complex with RbAp48 and HDAC3. [provided by RefSeq, Jul 2008]

• Gene Synonyms (histone deacetylase 4, histone deacetylase A, AHO3, BDMR, HA6116, HD4, HDAC-4, HDAC-A, HDACA,)
• NCBI Gene ID: 9759
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P56524
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

histone deacetylase 4 interacts with:

• acyl-CoA thioesterase 7
  ankyrin repeat and SOCS box containing 15
  ankyrin repeat domain 11
  ankyrin repeat domain 34A
  ankyrin repeat family A member 2
  anterior gradient 2, protein disulphide isomerase family member
  ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
  aryl-hydrocarbon receptor repressor
  aryl-hydrocarbon receptor repressor
  B cell receptor associated protein 31
  BCL6 corepressor
  BCL6 corepressor like 1
  BICD cargo adaptor 2
  brain enriched guanylate kinase associated
  BRMS1 transcriptional repressor and anoikis regulator
  calcium binding and coiled-coil domain 2
  calcyclin binding protein
  calmodulin regulated spectrin associated protein family member 2
  cell division cycle 37, HSP90 cochaperone
  centrosomal protein 70
  cerebellar degeneration related protein 2 like
  chaperonin containing TCP1 subunit 5
  chibby family member 1, beta catenin antagonist
  chromobox 1
  chromobox 3
  chromobox 5
  chromobox 5
  cingulin
  cleavage and polyadenylation specific factor 6
  coiled-coil domain containing 125
  coiled-coil domain containing 136
  C-terminal binding protein 1
  cullin 7
  cyclin D1 binding protein 1
  cysteine rich DPF motif domain containing 1
  DEAD-box helicase 19B
  DENN domain containing 1A
  DENN domain containing 4A
  DENN domain containing 4C
  DNA polymerase epsilon 3, accessory subunit
  DnaJ heat shock protein family (Hsp40) member B5
  DnaJ heat shock protein family (Hsp40) member B6
  DnaJ heat shock protein family (Hsp40) member B8
  DPY30 domain containing 1
  EF-hand domain containing 2
  EGF containing fibulin extracellular matrix protein 2
  establishment of sister chromatid cohesion N-acetyltransferase 2
  family with sequence similarity 110 member A
  family with sequence similarity 110 member B
  family with sequence similarity 53 member C
  FCH and double SH3 domains 2
  fibronectin type III and SPRY domain containing 2
  forkhead box P3
  golgin A6 family like 9
  GRB10 interacting GYF protein 1
  GRB10 interacting GYF protein 2
  GRB2 associated binding protein 2
  GRIP1 associated protein 1
  heat shock transcription factor 2 binding protein
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  histone deacetylase 4
  histone deacetylase 5
  histone deacetylase 7
  hook microtubule tethering protein 2
  IKAROS family zinc finger 1
  IKAROS family zinc finger 2
  IKAROS family zinc finger 3
  IKAROS family zinc finger 4
  inhibitor of CDK, cyclin A1 interacting protein 1
  inositol polyphosphate-5-phosphatase E
  Jun dimerization protein 2
  keratin 27
  keratin 40
  KH RNA binding domain containing, signal transduction associated 1
  kinesin family member 13B
  kinesin family member 1C
  LDOC1 regulator of NFKB signaling
  leucine rich repeat and fibronectin type III domain containing 1
  ligand dependent nuclear receptor corepressor
  LIM domain and actin binding 1
  lipin 3
  LUC7 like 2, pre-mRNA splicing factor
  lysine demethylase 5B
  MAPK associated protein 1
  maternal embryonic leucine zipper kinase
  microtubule associated protein 1S
  microtubule associated scaffold protein 2
  microtubule associated serine/threonine kinase 3
  midline 2
  MIF4G domain containing
  mitogen-activated protein kinase kinase kinase 21
  MORC family CW-type zinc finger 2
  multiple EGF like domains 10
  NAD kinase
  neuron navigator 1
  NFKB inhibitor delta
  NOP2/Sun RNA methyltransferase 2
  NSFL1 cofactor
  nuclear distribution C, dynein complex regulator
  nuclear receptor co-repressor 2
  nuclear receptor subfamily 1 group H member 3
  nucleus accumbens associated 1
  nudix hydrolase 4
  Obg like ATPase 1
  oxysterol binding protein like 6
  PDZ and LIM domain 5
  PHD finger protein 5A
  pleckstrin homology domain containing A7
  pleckstrin homology like domain family B member 2
  potassium channel tetramerization domain containing 3
  prefoldin subunit 6
  progesterone receptor membrane component 1
  protein kinase D2
  protein phosphatase, Mg2+/Mn2+ dependent 1H
  RAD50 interactor 1
  Ral GEF with PH domain and SH3 binding motif 2
  regulator of chromosome condensation 2
  RuvB like AAA ATPase 2
  serine and arginine repetitive matrix 1
  serine and arginine rich splicing factor 12
  SH3 domain containing ring finger 3
  signal induced proliferation associated 1 like 1
  SIN3 transcription regulator family member A
  sirtuin 1
  SLIT-ROBO Rho GTPase activating protein 2
  solute carrier family 25 member 13
  SS18L1 subunit of BAF chromatin remodeling complex
  SSX family member 2 interacting protein
  StAR related lipid transfer domain containing 13
  STIP1 homology and U-box containing protein 1
  stress induced phosphoprotein 1
  SUMO specific peptidase 1
  SUMO1 activating enzyme subunit 1
  synapse defective Rho GTPase homolog 1
  synaptotagmin binding cytoplasmic RNA interacting protein
  TAR DNA binding protein
  TBL1X receptor 1
  testis associated actin remodelling kinase 2
  testis specific 10
  thyroid hormone receptor associated protein 3
  tribbles pseudokinase 3
  tripartite motif containing 28
  tubulin beta 3 class III
  tubulin beta class I
  tuftelin interacting protein 11
  twist basic helix-loop-helix transcription factor 1
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta
  ubiquitin specific peptidase 21
  vir like m6A methyltransferase associated
  WASP family member 2
  zinc finger and BTB domain containing 21
  zinc finger and BTB domain containing 7B
  zinc finger E-box binding homeobox 2
  zinc finger MYND-type containing 12
  zinc finger protein 638

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.