LIMA1, LIM domain and actin binding 1

LIMA1, LIM domain and actin binding 1

• This gene encodes a cytoskeleton-associated protein that inhibits actin filament depolymerization and cross-links filaments in bundles. It is downregulated in some cancer cell lines. Alternatively spliced transcript variants encoding different isoforms have been described for this gene, and expression of some of the variants maybe independently regulated. [provided by RefSeq, Aug 2011]

• Gene Synonyms (LIM domain and actin-binding protein 1, 1110021C24Rik, epithelial protein lost in neoplasm beta, sterol regulatory element binding protein 3, EPLIN, LDLCQ8, SREBP3,)
• NCBI Gene ID: 51474
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UHB6
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

LIM domain and actin binding 1 interacts with:

• actin filament associated protein 1
  actin related protein 2/3 complex subunit 5 like
  AHNAK nucleoprotein
  anillin actin binding protein
  ankyrin repeat domain 34A
  ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
  autophagy related 16 like 1
  BMP2 inducible kinase
  calmodulin-like 3
  centrosomal protein 55
  cingulin
  coiled-coil domain containing 50
  coiled-coil domain containing 8
  coronin 1B
  cytochrome b reductase 1
  DENN domain containing 1A
  DENN domain containing 4C
  DEP domain containing 1B
  diablo IAP-binding mitochondrial protein
  EF-hand domain family member D2
  enhancer of mRNA decapping 3
  family with sequence similarity 110 member A
  family with sequence similarity 110 member B
  FCH and mu domain containing endocytic adaptor 2
  fibronectin type III domain containing 4
  filamin, beta
  G2 and S-phase expressed 1
  glutathione S-transferase kappa 1
  golgi associated PDZ and coiled-coil motif containing
  GRB10 interacting GYF protein 1
  histone deacetylase 7
  inositol polyphosphate-5-phosphatase E
  inverted formin 2
  leucine rich repeat and fibronectin type III domain containing 1
  leucine rich repeat containing 39
  leucine rich repeat kinase 2
  leucine rich repeats and calponin homology domain containing 3
  lipin 3
  MAPK associated protein 1
  methyltransferase like 14
  mitogen-activated protein kinase kinase kinase 21
  mitotic spindle positioning
  myosin VC
  myosin XIX
  myosin XVIIIA
  myosin, heavy polypeptide 10, non-muscle
  NAD kinase
  neuron navigator 1
  nexilin F-actin binding protein
  oxysterol binding protein like 6
  PALM2 and AKAP2 fusion
  pecanex 3
  PGAM family member 5, mitochondrial serine/threonine protein phosphatase
  pleckstrin homology and RhoGEF domain containing G6
  pleckstrin homology domain containing A4
  pleckstrin homology domain containing A5
  pleckstrin homology domain containing A7
  pleckstrin homology like domain family B member 2
  potassium channel tetramerization domain containing 10
  protein phosphatase 1 regulatory subunit 18
  protein phosphatase 1 regulatory subunit 9A
  protein phosphatase 1 regulatory subunit 9B
  protein phosphatase, Mg2+/Mn2+ dependent 1H
  PTEN induced kinase 1
  RAB3A interacting protein
  RAD18 E3 ubiquitin protein ligase
  RAP2C, member of RAS oncogene family
  regulatory associated protein of MTOR complex 1
  Rho GTPase activating protein 21
  ring finger protein 168
  serine and arginine rich splicing factor 12
  SH3 domain containing ring finger 3
  slingshot protein phosphatase 2
  sperm antigen with calponin homology and coiled-coil domains 1
  StAR related lipid transfer domain containing 13
  stonin 2
  synapse defective Rho GTPase homolog 1
  taperin
  transmembrane p24 trafficking protein 10
  UBX domain protein 2A
  UBX domain protein 6
  WD repeat domain 77
  ZFP41 zinc finger protein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.