SAE1, SUMO1 activating enzyme subunit 1

SAE1, SUMO1 activating enzyme subunit 1

• Posttranslational modification of proteins by the addition of the small protein SUMO (see SUMO1; MIM 601912), or sumoylation, regulates protein structure and intracellular localization. SAE1 and UBA2 (MIM 613295) form a heterodimer that functions as a SUMO-activating enzyme for the sumoylation of proteins (Okuma et al., 1999 [PubMed 9920803]).[supplied by OMIM, Mar 2010]

• Gene Synonyms (SUMO-activating enzyme subunit 1, SUMO-1 activating enzyme E1 N subunit, SUMO-1 activating enzyme subunit 1, activator of SUMO1, sentrin/SUMO-activating protein AOS1, ubiquitin-like 1-activating enzyme E1A, ubiquitin-like protein SUMO-1 activating enzyme, AOS1, HSPC140, SUA1, UBLE1A,)
• NCBI Gene ID: 10055
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R0R4
  UNIPROT ID#>>Q9UBE0
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

SUMO1 activating enzyme subunit 1 interacts with:

• dipeptidyl peptidase 9
  dual specificity phosphatase 28
  dynamin 1 like
  egl-9 family hypoxia inducible factor 3
  ER degradation enhancing alpha-mannosidase like protein 3
  Fas associated factor family member 2
  leucine rich repeat kinase 2
  mitotic arrest deficient 2 like 2
  NPL4 homolog, ubiquitin recognition factor
  O-sialoglycoprotein endopeptidase
  pantothenate kinase 4 (inactive)
  phosphodiesterase 12
  pleckstrin homology domain containing A4
  polyglutamine binding protein 1
  regulation of nuclear pre-mRNA domain containing 1B
  small ubiquitin-like modifier 3
  TP53 regulating kinase
  tripartite motif containing 28
  tRNA methyltransferase 10A
  ubiquilin 2
  ubiquitin conjugating enzyme E2 E3
  ubiquitin specific peptidase 39
  ubiquitin-conjugating enzyme E2I
  unc-79 homolog, NALCN channel complex subunit
  WD repeat domain 4

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.