KDM5B, lysine demethylase 5B

KDM5B, lysine demethylase 5B

• This gene encodes a lysine-specific histone demethylase that belongs to the jumonji/ARID domain-containing family of histone demethylases. The encoded protein is capable of demethylating tri-, di- and monomethylated lysine 4 of histone H3. This protein plays a role in the transcriptional repression or certain tumor suppressor genes and is upregulated in certain cancer cells. This protein may also play a role in genome stability and DNA repair. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]

• Gene Synonyms (CT31, JARID1B, MRT65, PLU-1, PLU1, PPP1R98, PUT1, RBBP2H1A, RBP2-H1, lysine-specific demethylase 5B, [histone H3]-trimethyl-L-lysine(4) demethylase 5B, cancer/testis antigen 31, histone demethylase JARID1B, jumonji, AT rich interactive domain 1B, jumonji/ARID domain-containing protein 1B, lysine (K)-specific demethylase 5B, protein phosphatase 1, regulatory subunit 98, putative DNA/chromatin binding motif, retinoblastoma-binding protein 2 homolog 1, retinoblastoma-binding protein 2, homolog 1A,)
• NCBI Gene ID: 10765
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9UGL1
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

lysine demethylase 5B interacts with:

• AT-rich interaction domain 1B
  BMP2 inducible kinase
  bromodomain containing 4
  drebrin like
  family with sequence similarity 90 member A1
  F-box and WD repeat domain containing 11
  histone deacetylase 7
  lysine demethylase 1A
  metastasis associated 1 family member 3
  methyl-CpG binding domain protein 3
  pecanex 1
  pleckstrin homology domain containing A4
  PR/SET domain 13
  REST corepressor 1
  Rho related BTB domain containing 2
  ring finger protein 43
  RNA binding motif protein 15B
  SLIT and NTRK like family member 3
  solute carrier family 39 member 6
  transmembrane protein 121B
  TSPY like 6
  vestigial like family member 3
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.