SRGAP2, SLIT-ROBO Rho GTPase activating protein 2

SRGAP2, SLIT-ROBO Rho GTPase activating protein 2

• This locus encodes a member of the SLIT-ROBO Rho GTPase activating protein family. The encoded protein stimulates GTPase activity of Rac1, and plays a role in cortical neuron development. This locus has several paralogs on human chromosome 1 resulting from segmental duplication. While this locus itself is conserved among various species, the paralogs are found only in the genus Homo, and not in the genomes of non-human great apes. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Jul 2014]

• Gene Synonyms (ARHGAP34, FNBP2, SRGAP2A, SRGAP3, SLIT-ROBO Rho GTPase-activating protein 2, SLIT-ROBO GAP2, formin-binding protein 2, rho GTPase-activating protein 34,)
• NCBI Gene ID: 23380
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B7Z3G4
  UNIPROT ID#>>O75044
  UNIPROT ID#>>B7ZM87
  UNIPROT ID#>>A0A075B7B5
  UNIPROT ID#>>B4DFE5
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

SLIT-ROBO Rho GTPase activating protein 2 interacts with:

• ankyrin repeat domain 34A
  ArfGAP with GTPase domain, ankyrin repeat and PH domain 1
  ATPase family AAA domain containing 3A
  aurora kinase A interacting protein 1
  centrosomal protein 19
  chibby family member 1, beta catenin antagonist
  cingulin
  DENN domain containing 1A
  DENN domain containing 4C
  DEP domain containing 1B
  DISC1 scaffold protein
  enhancer of mRNA decapping 3
  exocyst complex component 1
  family with sequence similarity 110 member A
  family with sequence similarity 110 member B
  family with sequence similarity 53 member C
  GRB10 interacting GYF protein 1
  GRB10 interacting GYF protein 2
  HECT domain E3 ubiquitin protein ligase 1
  histone deacetylase 7
  inositol polyphosphate-5-phosphatase E
  intersectin 2
  leucine rich repeat and fibronectin type III domain containing 1
  leucine zipper protein 4
  LIM domain and actin binding 1
  lipin 3
  MAPK associated protein 1
  mitogen-activated protein kinase kinase kinase 21
  myosin IG
  NAD kinase
  neuron navigator 1
  oxysterol binding protein like 6
  pleckstrin homology domain containing A5
  pleckstrin homology domain containing A7
  pleckstrin homology like domain family B member 2
  potassium channel tetramerization domain containing 3
  protein phosphatase, Mg2+/Mn2+ dependent 1H
  RAB3A interacting protein
  Ral GEF with PH domain and SH3 binding motif 2
  regulatory associated protein of MTOR complex 1
  serine and arginine rich splicing factor 12
  SH3 domain binding protein 4
  SH3 domain containing ring finger 3
  signal induced proliferation associated 1 like 1
  StAR related lipid transfer domain containing 13
  synapse defective Rho GTPase homolog 1
  tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2
  tripartite motif family like 2
  ubiquitin specific peptidase 21
  vir like m6A methyltransferase associated
  YLP motif containing 1
  zinc finger and BTB domain containing 21
  zinc finger protein 638

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.