HGS, hepatocyte growth factor-regulated tyrosine kinase substrate

HGS, hepatocyte growth factor-regulated tyrosine kinase substrate

• The protein encoded by this gene regulates endosomal sorting and plays a critical role in the recycling and degradation of membrane receptors. The encoded protein sorts monoubiquitinated membrane proteins into the multivesicular body, targeting these proteins for lysosome-dependent degradation. [provided by RefSeq, Dec 2010]

• Gene Synonyms (hepatocyte growth factor-regulated tyrosine kinase substrate, human growth factor-regulated tyrosine kinase substrate, protein pp110, HRS,)
• NCBI Gene ID: 9146
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O14964
  UNIPROT ID#>>A0A0S2Z4R4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

hepatocyte growth factor-regulated tyrosine kinase substrate interacts with:

• abl interactor 2
  acyl-CoA thioesterase 11
  adenine nucleotide translocase lysine methyltransferase
  adenosylhomocysteinase like 1
  ADP ribosylation factor interacting protein 2
  ADP ribosylation factor like GTPase 6 interacting protein 1
  A-kinase anchoring protein 8 like
  ankyrin repeat and SOCS box containing 12
  ankyrin repeat domain 55
  armadillo repeat containing 7
  armadillo repeat containing 8
  arrestin domain containing 3
  ataxin 1 like
  BCAS2 pre-mRNA processing factor
  BCL2 binding component 3
  Bet1 golgi vesicular membrane trafficking protein
  BLOC-1 related complex subunit 6
  BMP/retinoic acid inducible neural specific 3
  brain enriched guanylate kinase associated
  BRD4 interacting chromatin remodeling complex associated protein like
  centrosomal protein 55
  centrosomal protein 57 like 1
  centrosomal protein 63
  centrosomal protein 68
  chromosome 1 open reading frame 94
  chromosome 11 open reading frame 1
  chromosome 20 open reading frame 173
  chromosome 9 open reading frame 24
  citron rho-interacting serine/threonine kinase
  cleavage stimulation factor subunit 2 tau variant
  coiled-coil domain containing 103
  coiled-coil domain containing 114
  coiled-coil domain containing 136
  coiled-coil domain containing 196
  coiled-coil domain containing 33
  component of oligomeric golgi complex 8
  CTTNBP2 N-terminal like
  cytochrome b5 reductase 2
  DAZ associated protein 2
  deltex E3 ubiquitin ligase 2
  deltex E3 ubiquitin ligase 3L
  deuterosome assembly protein 1
  dishevelled associated activator of morphogenesis 2
  DnaJ heat shock protein family (Hsp40) member C5
  DPY30 domain containing 1
  DSN1 component of MIS12 kinetochore complex
  dynactin subunit 2
  EF-hand domain containing 2
  EGF like domain multiple 7
  euchromatic histone lysine methyltransferase 2
  exocyst complex component 3 like 1
  exocyst complex component 5
  exocyst complex component 7
  exocyst complex component 8
  family with sequence similarity 166 member A
  family with sequence similarity 168 member A
  family with sequence similarity 185 member A
  FCH and double SH3 domains 2
  fibronectin type III and SPRY domain containing 2
  fibronectin type III domain containing 11
  fidgetin, microtubule severing factor
  flotillin 1
  forkhead box D4 like 1
  formimidoyltransferase cyclodeaminase
  G kinase anchoring protein 1
  glutamyl-tRNA amidotransferase subunit C
  golgi associated, gamma adaptin ear containing, ARF binding protein 2
  golgi transport 1B
  golgin A6 family like 9
  golgin A7 family member B
  guanylate cyclase activator 1C
  HAUS augmin like complex subunit 1
  heat shock transcription factor Y-linked 1
  heterogeneous nuclear ribonucleoprotein D like
  HGH1 homolog
  HSPA (Hsp70) binding protein 1
  ILK associated serine/threonine phosphatase
  importin 4
  inhibitor of growth family member 5
  integrator complex subunit 4
  intraflagellar transport 74
  islet cell autoantigen 1 like
  itchy E3 ubiquitin protein ligase
  janus kinase and microtubule interacting protein 2
  jumonji domain containing 7
  keratin 24
  keratin 25
  keratin 26
  keratin 27
  keratin 39
  keratin 40
  keratin 76
  keratin associated protein 19-5
  keratin associated protein 26-1
  keratin associated protein 7-1
  KIAA0753
  KIAA0825
  Kruppel like factor 4
  LDOC1 regulator of NFKB signaling
  leucine rich adaptor protein 1
  leucine rich repeat containing 61
  leucine rich repeats and immunoglobulin like domains 1
  lipopolysaccharide induced TNF factor
  lysosomal protein transmembrane 4 beta
  MAGE family member D1
  mediator complex subunit 21
  mediator complex subunit 25
  mediator complex subunit 30
  mediator complex subunit 4
  mediator complex subunit 7
  Meis homeobox 3
  methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like
  methyltransferase like 27
  microtubule affinity regulating kinase 4
  MIF4G domain containing
  mindbomb E3 ubiquitin protein ligase 1
  mitogen-activated protein kinase 1 interacting protein 1 like
  Morf4 family associated protein 1 like 1
  NAD synthetase 1
  NDC80 kinetochore complex component
  NEDD4 like E3 ubiquitin protein ligase
  nuclear RNA export factor 1
  nucleoporin 54
  nucleoporin 62
  NUT family member 2F
  occludin
  odontogenic, ameloblast associated
  Opa interacting protein 5
  oxysterol binding protein like 5
  PBX/knotted 1 homeobox 2
  penta-EF-hand domain containing 1
  pentatricopeptide repeat domain 3
  peptidyl-tRNA hydrolase 2
  phospholipase A and acyltransferase 1
  phospholipase D family member 3
  plasmanylethanolamine desaturase 1
  pleckstrin homology domain containing B2
  PNMA family member 1
  pogo transposable element derived with ZNF domain
  POU class 6 homeobox 2
  proline rich 22
  proline rich 5
  proline, glutamate and leucine rich protein 1
  prolyl 4-hydroxylase subunit alpha 3
  prostate transmembrane protein, androgen induced 1
  proteasome subunit beta 11
  protein phosphatase 1 regulatory subunit 16A
  protein phosphatase 1 regulatory subunit 32
  protein phosphatase 2 regulatory subunit B''beta
  protein tyrosine phosphatase non-receptor type 23
  RAD50 interactor 1
  RAN guanine nucleotide release factor
  RANBP2-type and C3HC4-type zinc finger containing 1
  Ras association domain family member 4
  regulation of nuclear pre-mRNA domain containing 1A
  regulatory factor X6
  replication initiator 1
  Rho related BTB domain containing 3
  rhomboid 5 homolog 2
  ring finger protein 11
  R-spondin 4
  Sad1 and UNC84 domain containing 2
  Sec23 homolog A, COPII coat complex component
  secernin 1
  secretion regulating guanine nucleotide exchange factor
  secretory carrier membrane protein 3
  serine dehydratase
  serine/threonine kinase 32C
  SERTA domain containing 3
  SH3 domain containing kinase binding protein 1
  signal transducing adaptor molecule 2
  sorbin and SH3 domain containing 3
  sorting nexin 12
  sorting nexin 5
  sorting nexin 7
  SPC25 component of NDC80 kinetochore complex
  spermatogenesis associated 12
  spire type actin nucleation factor 2
  splicing factor 3a subunit 3
  splicing factor 3b subunit 3
  sprouty RTK signaling antagonist 2
  SS18L1 subunit of BAF chromatin remodeling complex
  stathmin 3
  STE20 like kinase
  suppressor APC domain containing 1
  synaptojanin 2 binding protein
  syntaxin 12
  target of myb1 like 1 membrane trafficking protein
  t-complex 11 like 2
  tektin 1
  tektin 5
  testis expressed 101
  tight junction protein 2
  TNF receptor associated factor 4
  TNF receptor associated protein 1
  trafficking from ER to golgi regulator
  trafficking kinesin protein 1
  transcription activation suppressor family member 2
  trans-golgi network protein 2
  translocase of inner mitochondrial membrane 10B
  translocase of inner mitochondrial membrane domain containing 1
  translocase of outer mitochondrial membrane 22
  transmembrane and coiled-coil domain family 2
  transmembrane protein 17
  tripartite motif containing 10
  tripartite motif containing 17
  tripartite motif containing 3
  tripartite motif containing 54
  tripartite motif containing 69
  tripartite motif containing 73
  tripartite motif family like 2
  tubulin beta class I
  ubiquilin 1
  ubiquilin 2
  ubiquilin 4
  ubiquilin like
  ubiquitin associated protein 2
  ubiquitin specific peptidase 54
  ubiquitination factor E4B
  UBX domain protein 11
  USH1 protein network component harmonin binding protein 1
  vacuolar protein sorting 4 homolog A
  vacuole membrane protein 1
  vestigial like family member 3
  VPS33B late endosome and lysosome associated
  VPS35 retromer complex component
  VPS37A subunit of ESCRT-I
  VPS37B subunit of ESCRT-I
  VPS37C subunit of ESCRT-I
  VPS37D subunit of ESCRT-I
  WASH complex subunit 1
  WD repeat domain 77
  yippee like 3
  zinc finger protein 302
  zinc finger protein 34
  zinc finger protein 430
  zinc finger protein 44

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.