DAZAP2, DAZ associated protein 2

DAZAP2, DAZ associated protein 2

• This gene encodes a proline-rich protein which interacts with the deleted in azoospermia (DAZ) and the deleted in azoospermia-like gene through the DAZ-like repeats. This protein also interacts with the transforming growth factor-beta signaling molecule SARA (Smad anchor for receptor activation), eukaryotic initiation factor 4G, and an E3 ubiquitinase that regulates its stability in splicing factor containing nuclear speckles. The encoded protein may function in various biological and pathological processes including spermatogenesis, cell signaling and transcription regulation, formation of stress granules during translation arrest, RNA splicing, and pathogenesis of multiple myeloma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

• Gene Synonyms (DAZ-associated protein 2, deleted in azoospermia associated protein 2, proline-rich transcript in brain, proline-rich transcript, brain-expressed protein, PRTB,)
• NCBI Gene ID: 9802
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q15038
  UNIPROT ID#>>A0A024R110
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

DAZ associated protein 2 interacts with:

• activation induced cytidine deaminase
  acyl-CoA thioesterase 7
  apoptosis antagonizing transcription factor
  ataxin 1 like
  AT-rich interaction domain 5A
  basic leucine zipper ATF-like transcription factor 2
  calcium binding and coiled-coil domain 2
  centrosomal protein 70
  chloride channel CLIC like 1
  chromosome 1 open reading frame 94
  CLK4 associating serine/arginine rich protein
  coiled-coil domain containing 120
  CUGBP Elav-like family member 5
  DAZ associated protein 2
  defective in cullin neddylation 1 domain containing 1
  deltex E3 ubiquitin ligase 2
  desumoylating isopeptidase 1
  DNA polymerase iota
  epithelial splicing regulatory protein 1
  epsin 1
  epsin 2
  epsin 3
  exonuclease 3'-5' domain containing 3
  family with sequence similarity 168 member A
  family with sequence similarity 83 member A
  fibrillin 3
  G protein signaling modulator 1
  glycerophosphodiester phosphodiesterase 1
  golgi associated, gamma adaptin ear containing, ARF binding protein 3
  hes related family bHLH transcription factor with YRPW motif 1
  inhibitor of CDK, cyclin A1 interacting protein 1
  interleukin 17 receptor B
  kelch like family member 42
  keratin associated protein 19-1
  keratin associated protein 19-3
  keratin associated protein 19-5
  keratin associated protein 19-7
  keratin associated protein 26-1
  keratin associated protein 6-1
  keratin associated protein 6-2
  keratin associated protein 8-1
  lymphoid enhancer binding factor 1
  maturin, neural progenitor differentiation regulator homolog
  mediator complex subunit 31
  MINDY lysine 48 deubiquitinase 1
  MINDY lysine 48 deubiquitinase 3
  mitogen-activated protein kinase 1 interacting protein 1 like
  myeloma overexpressed
  myozenin 3
  NEDD4 like E3 ubiquitin protein ligase
  nucleolar complex associated 4 homolog
  optineurin
  OTU deubiquitinase 7B
  OTU deubiquitinase with linear linkage specificity
  OTU deubiquitinase, ubiquitin aldehyde binding 2
  PDLIM1 interacting kinase 1 like
  penta-EF-hand domain containing 1
  phospholipid scramblase 4
  pleckstrin homology and FYVE domain containing 2
  pleckstrin homology domain containing B2
  pogo transposable element derived with ZNF domain
  POZ/BTB and AT hook containing zinc finger 1
  proline rich 13
  proline rich 20A
  proline rich 20B
  proline rich 20C
  proline rich 20D
  proline rich 20E
  RAB guanine nucleotide exchange factor 1
  RAD18 E3 ubiquitin protein ligase
  reticulophagy regulator family member 3
  Rhox homeobox family member 2
  ring finger protein 115
  ring finger protein 208
  ring finger protein 44
  RNA binding fox-1 homolog 1
  RNA binding fox-1 homolog 2
  RNA binding motif protein 11
  RNA binding motif protein 24
  RNA binding motif protein 43
  RNA binding protein, mRNA processing factor
  RNA guanine-7 methyltransferase activating subunit
  signal transducing adaptor molecule 2
  SMAD specific E3 ubiquitin protein ligase 2
  small ArfGAP2
  SRY-box transcription factor 6
  target of myb1 membrane trafficking protein
  terminal nucleotidyltransferase 5B
  terminal nucleotidyltransferase 5C
  testis expressed 37
  TNFAIP3 interacting protein 1
  TNFAIP3 interacting protein 3
  toll interacting protein
  trafficking from ER to golgi regulator
  transcription factor 7 like 1
  UBA domain containing 1
  ubiquilin 1
  ubiquilin 2
  ubiquilin 4
  ubiquitin associated and SH3 domain containing A
  ubiquitin associated and SH3 domain containing B
  ubiquitin associated protein 2
  ubiquitin conjugating enzyme E2 D4 (putative)
  ubiquitin conjugating enzyme E2 E3
  UBX domain protein 6
  UBX domain protein 7
  VENT homeobox
  VHL like
  VPS37C subunit of ESCRT-I
  WD repeat domain 73
  WW domain containing E3 ubiquitin protein ligase 1
  WW domain containing oxidoreductase
  YOD1 deubiquitinase
  zinc finger AN1-type containing 2A
  zinc finger AN1-type containing 2B
  zinc finger and BTB domain containing 32
  zinc finger CCCH-type containing 10
  zinc finger protein 34
  zinc finger protein 581

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.