NDC80, NDC80 kinetochore complex component

NDC80, NDC80 kinetochore complex component

• This gene encodes a component of the NDC80 kinetochore complex. The encoded protein consists of an N-terminal microtubule binding domain and a C-terminal coiled-coiled domain that interacts with other components of the complex. This protein functions to organize and stabilize microtubule-kinetochore interactions and is required for proper chromosome segregation. [provided by RefSeq, Oct 2011]

• Gene Synonyms (HEC, HEC1, HsHec1, KNTC2, TID3, hsNDC80, kinetochore protein NDC80 homolog, NDC80 homolog, kinetochore complex component, NDC80 kinetochore complex component homolog, highly expressed in cancer protein, highly expressed in cancer, rich in leucine heptad repeats, kinetochore associated 2, kinetochore protein Hec1, kinetochore-associated protein 2, retinoblastoma-associated protein HEC,)
• NCBI Gene ID: 10403
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A8K031
  UNIPROT ID#>>O14777
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

NDC80 kinetochore complex component interacts with:

• angiomotin like 2
  ATPase H+ transporting V1 subunit D
  BICD cargo adaptor 2
  biogenesis of lysosomal organelles complex 1 subunit 6
  BUB1, mitotic checkpoint serine/threonine kinase
  BUB1B, mitotic checkpoint serine/threonine kinase
  calcium binding and coiled-coil domain 1
  cancer antigen 1
  centromere protein H
  centrosomal protein 63
  coiled-coil alpha-helical rod protein 1
  coiled-coil domain containing 136
  coiled-coil domain containing 68
  DSN1 component of MIS12 kinetochore complex
  egl-9 family hypoxia inducible factor 3
  epidermal growth factor receptor pathway substrate 15 like 1
  exocyst complex component 1
  exocyst complex component 8
  family with sequence similarity 170 member A
  family with sequence similarity 9 member C
  HAUS augmin like complex subunit 1
  intraflagellar transport 20
  intraflagellar transport 81
  kelch like family member 12
  keratin 27
  kinesin light chain 3
  kinetochore scaffold 1
  kinetochore scaffold 1
  ligand of numb-protein X 1
  mediator complex subunit 4
  MIS12 kinetochore complex component
  MIS12 kinetochore complex component
  NDC80 kinetochore complex component
  NDC80 kinetochore complex component
  ninein
  NSL1 component of MIS12 kinetochore complex
  N-terminal glutamine amidase 1
  nuclear RNA export factor 1
  nudE neurodevelopment protein 1
  nudE neurodevelopment protein 1 like 1
  NUF2 component of NDC80 kinetochore complex
  pleckstrin homology domain containing A4
  polyamine modulated factor 1
  protein phosphatase 1 regulatory subunit 13B
  RUN and FYVE domain containing 4
  SAGA complex associated factor 29
  SNW domain containing 1
  SPC24 component of NDC80 kinetochore complex
  SPC25 component of NDC80 kinetochore complex
  spindle and centriole associated protein 1
  spindle and kinetochore associated complex subunit 1
  suppressor of glucose, autophagy associated 1
  SWI5 dependent homologous recombination repair protein 1
  syncoilin, intermediate filament protein
  taxilin alpha
  THO complex 7
  tuftelin interacting protein 11
  USH1 protein network component harmonin binding protein 1
  WASH complex subunit 1
  WASH complex subunit 3
  zinc finger protein 655
  ZW10 interacting kinetochore protein
  ZW10 interactor

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.