- Gene Overview
- Interaction Network
- Sequence Verification
ATP6V1D, ATPase H+ transporting V1 subunit D
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This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This gene encodes the V1 domain D subunit protein. [provided by RefSeq, Jul 2008]
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Gene Synonyms (V-type proton ATPase subunit D, ATPase, H+ transporting lysosomal, member M, ATPase, H+ transporting, lysosomal (vacuolar proton pump), ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D, H(+)-transporting two-sector ATPase, subunit M, V-ATPase 28 kDa accessory protein, V-ATPase D subunit, V-ATPase subunit D, vacuolar ATP synthase subunit D, vacuolar H-ATPase subunit D, vacuolar proton pump D subunit, vacuolar proton pump delta polypeptide, vacuolar proton pump subunit D, vacuolar proton-ATPase subunit D, ATP6M, VATD, VMA8,)
- NCBI Gene ID:
51382
- Species:
Homo sapiens (Human)
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UNIPROT ID#>>A0A024R683
UNIPROT ID#>>Q9Y5K8
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for this Gene »
Gene products are often involved in multiple pathways and networks within a living
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ATPase H+ transporting V1 subunit D interacts with:
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