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MRPL40, mitochondrial ribosomal protein L40

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MRPL40, mitochondrial ribosomal protein L40

  • Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Deletions in this gene may contribute to the etiology of velo-cardio-facial syndrome and DiGeorge syndrome. [provided by RefSeq, Jul 2008]

  • Gene Synonyms (39S ribosomal protein L40, mitochondrial, mitochondrial large ribosomal subunit protein mL40, nuclear localization signal-containing protein deleted in velocardiofacial syndrome, up-regulated in metastasis, L40mt, MRP-L22, MRP-L40, MRPL22, NLVCF, URIM,)
  • NCBI Gene ID: 64976
  • Species: Homo sapiens (Human)
  • UNIPROT ID#>>Q9NQ50
  • View the NCBI Database for this Gene »

The information on this page was collected from publicly accessible databases, and is periodically updated. Promega makes no claims to accuracy, or ownership of these genes.

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The information on this page was collected from publicly accessible databases, and is periodically updated. Promega makes no claims to accuracy, or ownership of these genes.

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