MRPL21, mitochondrial ribosomal protein L21

MRPL21, mitochondrial ribosomal protein L21

• Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding different isoforms were identified through sequence analysis although some may be subject to nonsense-mediated decay (NMD). [provided by RefSeq, Jul 2008]

• Gene Synonyms (39S ribosomal protein L21, mitochondrial, mitochondrial large ribosomal subunit protein bL21m, L21mt, MRP-L21,)
• NCBI Gene ID: 219927
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B4DXI4
  UNIPROT ID#>>Q7Z2W9
  UNIPROT ID#>>A0A024R5G7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

mitochondrial ribosomal protein L21 interacts with:

• bromodomain and WD repeat domain containing 3

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.