NUF2, NUF2 component of NDC80 kinetochore complex

NUF2, NUF2 component of NDC80 kinetochore complex

• This gene encodes a protein that is highly similar to yeast Nuf2, a component of a conserved protein complex associated with the centromere. Yeast Nuf2 disappears from the centromere during meiotic prophase when centromeres lose their connection to the spindle pole body, and plays a regulatory role in chromosome segregation. The encoded protein is found to be associated with centromeres of mitotic HeLa cells, which suggests that this protein is a functional homolog of yeast Nuf2. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]

• Gene Synonyms (kinetochore protein Nuf2, NDC80 kinetochore complex component NUF2, NUF2, NDC80 kinetochore complex component, homolog, cancer/testis antigen 106, cell division cycle associated 1, cell division cycle-associated protein 1, hNuf2, hNuf2R, hsNuf2, CDCA1, CT106, NUF2R,)
• NCBI Gene ID: 83540
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9BZD4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

NUF2 component of NDC80 kinetochore complex interacts with:

• autophagy related 4A cysteine peptidase
  caveolae associated protein 1
  chromosome 6 open reading frame 141
  dystrobrevin binding protein 1
  egl-9 family hypoxia inducible factor 3
  pleckstrin homology like domain family B member 3
  SPC24 component of NDC80 kinetochore complex

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