NELFE, negative elongation factor complex member E

NELFE, negative elongation factor complex member E

• The protein encoded by this gene is part of a complex termed negative elongation factor (NELF) which represses RNA polymerase II transcript elongation. This protein bears similarity to nuclear RNA-binding proteins; however, it has not been demonstrated that this protein binds RNA. The protein contains a tract of alternating basic and acidic residues, largely arginine (R) and aspartic acid (D). The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. [provided by RefSeq, Jul 2008]

• Gene Synonyms (negative elongation factor E, RD RNA-binding protein, RNA-binding protein RD, major histocompatibility complex gene RD, negative elongation factor polypeptide E, nuclear protein, D6S45, NELF-E, RD, RDBP, RDP,)
• NCBI Gene ID: 7936
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P18615
  UNIPROT ID#>>A0A1U9X830
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

negative elongation factor complex member E interacts with:

• arginine and serine rich coiled-coil 1
  autophagy related 16 like 1
  cactin, spliceosome C complex subunit
  coiled-coil domain containing 57
  DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
  elongation factor Tu GTP binding domain containing 2
  F-box and WD repeat domain containing 7
  microtubule associated scaffold protein 2
  negative elongation factor complex member A, Whsc2
  negative elongation factor complex member B
  negative elongation factor complex member C/D
  negative elongation factor complex member E
  nuclear cap binding protein subunit 2
  nuclear cap binding protein subunit 2
  nuclear receptor corepressor 1
  pleckstrin homology domain containing A4
  PYM homolog 1, exon junction complex associated factor
  RNA polymerase II associated protein 2
  splicing factor 3b subunit 1
  tankyrase
  tetratricopeptide repeat domain 29
  transmembrane protein 141
  vesicle associated membrane protein 3
  WD repeat domain 48
  WW domain containing E3 ubiquitin protein ligase 2

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.