NELFB, negative elongation factor complex member B

NELFB, negative elongation factor complex member B

• NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2; MIM 606026), either NELFC or NELFD (TH1L; MIM 605297), and NELFE (RDBP; MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1; MIM 603555) and SPT5 (SUPT5H; MIM 602102), to cause transcriptional pausing of RNA polymerase II (see MIM 180660) (Narita et al., 2003 [PubMed 12612062]).[supplied by OMIM, Mar 2008]

• Gene Synonyms (negative elongation factor B, cofactor of BRCA1, negative elongation factor protein B, COBRA1, NELF-B,)
• NCBI Gene ID: 25920
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8WX92
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

negative elongation factor complex member B interacts with:

• autophagy related 16 like 1
  DIMT1 rRNA methyltransferase and ribosome maturation factor
  elongator acetyltransferase complex subunit 6
  KIAA1191
  negative elongation factor complex member B
  negative elongation factor complex member C/D
  nuclear cap binding protein subunit 2
  potassium channel tetramerization domain containing 10
  ring finger protein 123
  tetrapeptide repeat homeobox 1

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