SKP1, S-phase kinase associated protein 1

SKP1, S-phase kinase associated protein 1

• This gene encodes a component of SCF complexes, which are composed of this protein, cullin 1, a ring-box protein, and one member of the F-box family of proteins. This protein binds directly to the F-box motif found in F-box proteins. SCF complexes are involved in the regulated ubiquitination of specific protein substrates, which targets them for degradation by the proteosome. Specific F-box proteins recognize different target protein(s), and many specific SCF substrates have been identified including regulators of cell cycle progression and development. Studies have also characterized the protein as an RNA polymerase II elongation factor. Alternative splicing of this gene results in two transcript variants. A related pseudogene has been identified on chromosome 7. [provided by RefSeq, Jul 2008]

• Gene Synonyms (S-phase kinase-associated protein 1, OCP-2, RNA polymerase II elongation factor-like protein OCP2, SIII, cyclin A/CDK2-associated p19, cyclin-A/CDK2-associated protein p19, organ of Corti protein 2, organ of Corti protein II, p19skp1, transcription elongation factor B polypeptide 1-like, EMC19, OCP-II, OCP2, SKP1A, TCEB1L, p19A,)
• NCBI Gene ID: 6500
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P63208
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

S-phase kinase associated protein 1 interacts with:

• AAR2 splicing factor
  adenosylhomocysteinase like 1
  APAF1 interacting protein
  ariadne RBR E3 ubiquitin protein ligase 1
  AT-rich interaction domain 1A
  aurora kinase A
  BAG cochaperone 3
  BCL6 corepressor
  BCL6 corepressor like 1
  beta-transducin repeat containing E3 ubiquitin protein ligase
  BORA aurora kinase A activator
  BTB and CNC homology 1, basic leucine zipper transcription factor 1
  BTG anti-proliferation factor 2
  calcyclin binding protein
  CDC23 cell division cycle 23
  cell division cycle 37, HSP90 cochaperone
  cell division cycle associated 3
  cereblon
  chromatin licensing and DNA replication factor 1
  chromobox 4
  chromobox 8
  coiled-coil domain containing 22
  coiled-coil domain containing 6
  coiled-coil domain containing 8
  COP1 E3 ubiquitin ligase
  COP9 signalosome subunit 3
  COP9 signalosome subunit 4
  COP9 signalosome subunit 5
  COP9 signalosome subunit 6
  coronin 1C
  cryptochrome 2 (photolyase-like)
  cullin 1
  cullin 3
  cullin 4A
  cullin 5
  cullin 7
  cullin 9
  cullin associated and neddylation dissociated 1
  cyclin-dependent kinase 1
  cytoskeleton associated protein 4
  DAB2 interacting protein
  DDB1 and CUL4 associated factor 4
  DDB1 and CUL4 associated factor 7
  DEAD-box helicase 19B
  dynamin 1 like
  dynein light chain LC8-type 1
  dynein light chain LC8-type 1
  dynein light chain LC8-type 2
  egl-9 family hypoxia inducible factor 3
  elongation factor Tu GTP binding domain containing 2
  EMAP like 4
  embryonic ectoderm development
  eukaryotic elongation factor 2 kinase
  family with sequence similarity 172 member A
  Fas associated factor 1
  F-box and leucine rich repeat protein 12
  F-box and leucine rich repeat protein 14
  F-box and leucine rich repeat protein 15
  F-box and leucine rich repeat protein 16
  F-box and leucine rich repeat protein 17
  F-box and leucine rich repeat protein 18
  F-box and leucine rich repeat protein 19
  F-box and leucine rich repeat protein 2
  F-box and leucine rich repeat protein 20
  F-box and leucine rich repeat protein 22
  F-box and leucine rich repeat protein 3
  F-box and leucine rich repeat protein 4
  F-box and leucine rich repeat protein 5
  F-box and leucine rich repeat protein 6
  F-box and leucine rich repeat protein 7
  F-box and leucine rich repeat protein 8
  F-box and leucine-rich repeat protein 16
  F-box and leucine-rich repeat protein 3
  F-box and leucine-rich repeat protein 8
  F-box and WD repeat domain containing 11
  F-box and WD repeat domain containing 12
  F-box and WD repeat domain containing 2
  F-box and WD repeat domain containing 5
  F-box and WD repeat domain containing 7
  F-box and WD repeat domain containing 8
  F-box and WD repeat domain containing 9
  F-box and WD-40 domain protein 11
  F-box and WD-40 domain protein 14
  F-box and WD-40 domain protein 5
  F-box DNA helicase 1
  F-box protein 10
  F-box protein 11
  F-box protein 15
  F-box protein 15
  F-box protein 16
  F-box protein 17
  F-box protein 2
  F-box protein 21
  F-box protein 21
  F-box protein 22
  F-box protein 24
  F-box protein 25
  F-box protein 27
  F-box protein 28
  F-box protein 3
  F-box protein 30
  F-box protein 31
  F-box protein 32
  F-box protein 33
  F-box protein 34
  F-box protein 36
  F-box protein 38
  F-box protein 4
  F-box protein 40
  F-box protein 41
  F-box protein 42
  F-box protein 43
  F-box protein 44
  F-box protein 45
  F-box protein 45
  F-box protein 46
  F-box protein 48
  F-box protein 5
  F-box protein 6
  F-box protein 7
  F-box protein 8
  F-box protein 9
  FMR1 autosomal homolog 1
  GIT ArfGAP 1
  glial cells missing transcription factor 1
  glomulin, FKBP associated protein
  H2A clustered histone 4
  H4 clustered histone 1
  hes related family bHLH transcription factor with YRPW motif 1
  HEXIM P-TEFb complex subunit 1
  hypoxia inducible factor 1 subunit alpha inhibitor
  innate immunity activator
  IQ motif containing B1
  kelch like family member 12
  Kruppel like factor 4
  La ribonucleoprotein 7, transcriptional regulator
  large tumor suppressor kinase 2
  lectin, galactoside-binding, soluble, 3 binding protein
  lysine demethylase 2A
  lysine demethylase 2B
  lysine methyltransferase 5A
  MAGE family member C2
  mediator complex subunit 21
  mediator complex subunit 6
  methylphosphate capping enzyme
  microtubule associated scaffold protein 1
  mitogen-activated protein kinase kinase kinase kinase 1
  MTSS I-BAR domain containing 1
  multiple coagulation factor deficiency 2, ER cargo receptor complex subunit
  MYC binding protein 2
  NDC80 kinetochore complex component
  nicotinamide nucleotide adenylyltransferase 2
  NUAK family kinase 1
  nucleic acid binding protein 2
  obscurin like cytoskeletal adaptor 1
  phosphatidylinositol-5-phosphate 4-kinase type 2 beta
  phosphatidylinositol-5-phosphate 4-kinase type 2 gamma
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  polycomb group ring finger 1
  potassium channel tetramerization domain containing 9
  PPARG coactivator 1 alpha
  pre-mRNA processing factor 8
  proteasome activator subunit 3
  proteasome inhibitor subunit 1
  Rac/Cdc42 guanine nucleotide exchange factor 6
  Ras association domain family member 1
  receptor interacting serine/threonine kinase 4
  RecQ like helicase 4
  Rho guanine nucleotide exchange factor 7
  ring finger and CCCH-type domains 1
  RING1 and YY1 binding protein
  ring-box 1
  RNA binding motif protein 14
  Sad1 and UNC84 domain containing 2
  SEC23 homolog B, COPII coat complex component
  serine/threonine/tyrosine interacting protein
  SGT1 homolog, MIS12 kinetochore complex assembly cochaperone
  small nuclear ribonucleoprotein U1 subunit 70
  S-phase kinase associated protein 1
  S-phase kinase associated protein 2
  S-phase kinase-associated protein 2
  splicing factor 3b subunit 3
  SSU72 homolog, RNA polymerase II CTD phosphatase
  stem-loop binding protein
  SUZ12 polycomb repressive complex 2 subunit
  synuclein alpha
  talin 2
  TANK binding kinase 1
  telomeric repeat binding factor 1
  testis expressed 101
  tetratricopeptide repeat domain 21A
  tetratricopeptide repeat domain 9C
  TNF receptor associated factor 1
  TNFAIP3 interacting protein 2
  transcription factor AP-4
  transducin beta like 1 X-linked
  transformation/transcription domain associated protein
  tripartite motif containing 21
  tubulin gamma 1
  tubulin gamma complex associated protein 3
  tumor protein p53
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  ubiquitin C
  ubiquitin conjugating enzyme E2 B
  ubiquitin conjugating enzyme E2 D1
  ubiquitin conjugating enzyme E2 M
  ubiquitin like with PHD and ring finger domains 2
  ubiquitin specific peptidase 15
  ubiquitin specific peptidase 37
  UBX domain protein 7
  valosin containing protein
  vir like m6A methyltransferase associated
  YY1 associated factor 2
  zinc and ring finger 3
  zinc finger C3HC-type containing 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.