EED, embryonic ectoderm development

EED, embryonic ectoderm development

• This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein interacts with enhancer of zeste 2, the cytoplasmic tail of integrin beta7, immunodeficiency virus type 1 (HIV-1) MA protein, and histone deacetylase proteins. This protein mediates repression of gene activity through histone deacetylation, and may act as a specific regulator of integrin function. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

• Gene Synonyms (polycomb protein EED, WD protein associating with integrin cytoplasmic tails 1, embryonic ectoderm development protein, COGIS, HEED, WAIT1,)
• NCBI Gene ID: 8726
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O75530
  UNIPROT ID#>>E9PJK2
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

embryonic ectoderm development interacts with:

• actin related protein 8
  activity dependent neuroprotector homeobox
  ADP ribosylation factor GTPase activating protein 2
  ADP ribosylation factor like GTPase 5B
  AE binding protein 2
  Aly/REF export factor
  apolipoprotein B mRNA editing enzyme catalytic subunit 3B
  apoptotic chromatin condensation inducer 1
  arginine and glutamate rich 1
  ASXL transcriptional regulator 1
  AT-hook containing transcription factor 1
  BCAS2 pre-mRNA processing factor
  BCL6 corepressor
  beta-transducin repeat containing E3 ubiquitin protein ligase
  biogenesis of ribosomes BRX1
  bromodomain adjacent to zinc finger domain 1A
  bromodomain adjacent to zinc finger domain 1B
  bromodomain adjacent to zinc finger domain 2A
  castor zinc finger 1
  CCAAT enhancer binding protein zeta
  CCCTC-binding factor
  centromere protein V
  chaperonin containing TCP1 subunit 2
  chaperonin containing TCP1 subunit 7
  chromatin accessibility complex subunit 1
  chromobox 3
  chromobox 7
  chromobox 8
  cleavage and polyadenylation specific factor 1
  cleavage and polyadenylation specific factor 6
  cleavage and polyadenylation specific factor 7
  CLK4 associating serine/arginine rich protein
  coactivator associated arginine methyltransferase 1
  coiled-coil domain containing 71
  crooked neck pre-mRNA splicing factor 1
  cullin associated and neddylation dissociated 1
  CWC22 spliceosome associated protein homolog
  cyclin dependent kinase 2 associated protein 2
  cytoskeleton associated protein 5
  DAZ associated protein 1
  DDB1 and CUL4 associated factor 13
  DDB1 and CUL4 associated factor 7
  DEAD-box helicase 17
  DEAD-box helicase 18
  DEAD-box helicase 27
  DEAD-box helicase 42
  DEAD-box helicase 47
  death inducer-obliterator 1
  decapping enzyme, scavenger
  destrin, actin depolymerizing factor
  DExD-box helicase 21
  DExD-box helicase 39A
  DExD-box helicase 50
  DExD-box helicase 52
  DNA polymerase epsilon 3, accessory subunit
  dual specificity phosphatase 23
  dynein light chain LC8-type 2
  E1A binding protein p400
  EBNA1 binding protein 2
  elongation factor Tu GTP binding domain containing 2
  elongin BC and polycomb repressive complex 2 associated protein
  embryonic ectoderm development
  EMG1 N1-specific pseudouridine methyltransferase
  enhancer of polycomb homolog 1
  enhancer of polycomb homolog 2
  euchromatic histone lysine methyltransferase 1
  euchromatic histone lysine methyltransferase 2
  eukaryotic translation initiation factor 4A3
  exosome component 4
  far upstream element binding protein 1
  far upstream element binding protein 3
  F-box and WD repeat domain containing 11
  F-box protein 11
  flotillin 1
  FtsJ RNA 2'-O-methyltransferase 3
  G protein nucleolar 3
  GATA zinc finger domain containing 2B
  gem nuclear organelle associated protein 5
  general transcription factor IIIC subunit 3
  general transcription factor IIIC subunit 4
  glutaredoxin 3
  glyoxylate reductase 1 homolog
  GTP binding protein 4
  H1.10 linker histone
  H4 histone 16
  HEAT repeat containing 1
  heterochromatin protein 1 binding protein 3
  heterogeneous nuclear ribonucleoprotein A0
  heterogeneous nuclear ribonucleoprotein A3
  heterogeneous nuclear ribonucleoprotein D like
  heterogeneous nuclear ribonucleoprotein R
  heterogeneous nuclear ribonucleoprotein U like 1
  heterogeneous nuclear ribonucleoprotein U like 2
  histone deacetylase 3
  histone deacetylase 8
  homeobox B13
  IMP U3 small nucleolar ribonucleoprotein 3
  integrator complex subunit 1
  integrator complex subunit 3
  inturned planar cell polarity protein
  kinesin family member 20A
  kinesin family member 4A
  lamin B2
  ligand dependent nuclear receptor corepressor
  LUC7 like 3 pre-mRNA splicing factor
  lysine demethylase 1A
  lysine demethylase 2A
  lysine methyltransferase 5A
  macroH2A.1 histone
  macroH2A.2 histone
  magnesium transporter 1
  mago homolog B, exon junction complex subunit
  mannosidase alpha class 1B member 1
  matrin 3
  MAX dimerization protein MGA
  mediator complex subunit 14
  mediator of DNA damage checkpoint 1
  metal response element binding transcription factor 2
  metastasis associated 1
  microtubule associated protein 1 light chain 3 beta
  mitochondrial ribosomal protein L20
  Mtr4 exosome RNA helicase
  MYB binding protein 1a
  myelin expression factor 2
  N-acetyltransferase 10
  N-alpha-acetyltransferase 40, NatD catalytic subunit
  NIPBL cohesin loading factor
  N-myc downstream regulated 1
  NOC2 like nucleolar associated transcriptional repressor
  NOP56 ribonucleoprotein
  NOP58 ribonucleoprotein
  NPR2 like, GATOR1 complex subunit
  NRDE-2, necessary for RNA interference, domain containing
  nuclear receptor corepressor 1
  nuclear RNA export factor 1
  nucleolar and coiled-body phosphoprotein 1
  nucleolar protein 10
  nucleolar protein 11
  nucleolar protein 6
  nucleolar protein interacting with the FHA domain of MKI67
  nucleolar protein with MIF4G domain 1
  nucleophosmin/nucleoplasmin 3
  nucleoporin 107
  nucleoporin 133
  nucleoporin 160
  nucleoporin 188
  nucleoporin 205
  nucleoporin 210
  nucleoporin 85
  nucleoporin 93
  nudix hydrolase 21
  oligosaccharyltransferase complex non-catalytic subunit
  paraspeckle component 1
  partner of NOB1 homolog
  PDS5 cohesin associated factor A
  PDS5 cohesin associated factor B
  peptidylprolyl isomerase domain and WD repeat containing 1
  peroxiredoxin 4
  PHD finger protein 19
  plakophilin 3
  pleckstrin homology domain containing A4
  pogo transposable element derived with ZNF domain
  poly(U) binding splicing factor 60
  polybromo 1
  polycomb group ring finger 1
  polycomb group ring finger 6
  polyhomeotic homolog 3
  polynucleotide kinase 3'-phosphatase
  PR/SET domain 14
  praja ring finger ubiquitin ligase 1
  pre-mRNA processing factor 19
  pre-mRNA processing factor 38A
  pre-mRNA processing factor 40 homolog A
  pre-mRNA processing factor 6
  pre-mRNA processing factor 8
  programmed cell death 11
  prohibitin 2
  pumilio RNA binding family member 3
  RAB guanine nucleotide exchange factor 1
  RAB14, member RAS oncogene family
  RAB1B, member RAS oncogene family
  RAD50 double strand break repair protein
  RALY heterogeneous nuclear ribonucleoprotein
  receptor for activated C kinase 1
  replication timing regulatory factor 1
  ribosomal L1 domain containing 1
  ribosomal protein L13a
  ribosomal protein L14
  ribosomal protein L23
  ribosomal protein L35
  ribosomal RNA processing 12 homolog
  ribosomal RNA processing 9, U3 small nucleolar RNA binding protein
  RING1 and YY1 binding protein
  RNA binding motif protein 12B
  RNA binding motif protein 14
  RNA binding motif protein 15
  RNA binding motif protein 25
  RNA binding motif protein 28
  RNA binding motif protein 39
  RNA binding motif protein X-linked
  RNA terminal phosphate cyclase like 1
  RPTOR independent companion of MTOR complex 2
  RuvB like AAA ATPase 2
  SAFB like transcription modulator
  scaffold attachment factor B2
  SEC23 homolog B, COPII coat complex component
  SEC24 homolog B, COPII coat complex component
  SEC24 homolog C, COPII coat complex component
  SEC31 homolog A, COPII coat complex component
  selenium binding protein 1
  septin 9
  serine and arginine rich splicing factor 10
  serine and arginine rich splicing factor 8
  serine/arginine repetitive matrix 2
  serrate, RNA effector molecule
  SET and MYND domain containing 3
  signal recognition particle 72
  SIN3 transcription regulator family member A
  sirtuin 1
  small nuclear ribonucleoprotein U5 subunit 200
  solute carrier family 39 member 3
  solute carrier family 39 member 9
  spen family transcriptional repressor
  spermatid perinuclear RNA binding protein
  sphingomyelin phosphodiesterase 3
  sphingomyelin phosphodiesterase 4
  splicing factor 3a subunit 1
  splicing factor 3a subunit 3
  splicing factor 3b subunit 1
  splicing factor 3b subunit 3
  splicing factor 3b subunit 6
  SPOUT domain containing methyltransferase 1
  SPT16 homolog, facilitates chromatin remodeling subunit
  SR-related CTD associated factor 4
  stromal antigen 1
  structural maintenance of chromosomes 3
  structural maintenance of chromosomes flexible hinge domain containing 1
  SUZ12 polycomb repressive complex 2 subunit
  synaptotagmin binding cytoplasmic RNA interacting protein
  TAR DNA binding protein
  TBL1X receptor 1
  thioredoxin domain containing 5
  THO complex 2
  thyroid hormone receptor interactor 12
  trafficking protein particle complex 5
  transcription elongation regulator 1
  transducin beta like 3
  transformer 2 alpha homolog
  trimethylguanosine synthase 1
  tripartite motif containing 28
  TSC22 domain family member 1
  tubulin alpha 1b
  tubulin alpha 1c
  U2 small nuclear RNA auxiliary factor 2
  ubiquitin conjugating enzyme E2 M
  ubiquitin conjugating enzyme E2 W
  ubiquitin like with PHD and ring finger domains 2
  UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2
  UTP14A small subunit processome component
  UTP20 small subunit processome component
  vacuolar protein sorting 45 homolog
  VPS53 subunit of GARP complex
  WD repeat domain 3
  WIZ zinc finger
  ZFP42 zinc finger protein
  zinc finger BED-type containing 8
  zinc finger protein 326
  zinc finger protein 638
  zinc finger protein 687

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.