GEMIN5, gem nuclear organelle associated protein 5

GEMIN5, gem nuclear organelle associated protein 5

• This gene encodes a WD repeat protein that is a component of the survival of motor neurons (SMN) complex. The SMN complex plays a critical role in mRNA splicing through the assembly of spliceosomal small nuclear ribonucleoproteins (snRNPs), and may also mediate the assembly and transport of other classes of ribonucleoproteins. The encoded protein is the snRNA-binding component of the SMN complex. Dysregulation of this gene may play a role in alternative mRNA splicing and tumor cell motility. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

• Gene Synonyms (gem-associated protein 5, GEMIN-5,)
• NCBI Gene ID: 25929
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q8TEQ6
  UNIPROT ID#>>B7ZLC9
  UNIPROT ID#>>Q58EZ8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

gem nuclear organelle associated protein 5 interacts with:

• AAR2 splicing factor
  autophagy related 16 like 1
  bromodomain containing 7
  bromodomain containing 9
  catechol-O-methyltransferase domain containing 1
  centromere protein J
  chromobox 2
  copine 5
  CXXC finger protein 1
  elongator acetyltransferase complex subunit 3
  F-box protein 6
  GAR1 ribonucleoprotein
  gem nuclear organelle associated protein 4
  gem nuclear organelle associated protein 6
  gem nuclear organelle associated protein 7
  gem nuclear organelle associated protein 8
  glutamine amidotransferase like class 1 domain containing 1
  La ribonucleoprotein 7, transcriptional regulator
  leucine rich repeat containing G protein-coupled receptor 4
  LSM11, U7 small nuclear RNA associated
  mediator complex subunit 15
  mediator complex subunit 4
  mindbomb E3 ubiquitin protein ligase 1
  OTU deubiquitinase with linear linkage specificity
  PAF1 homolog, Paf1/RNA polymerase II complex component
  PIH1 domain containing 1
  pleckstrin homology domain containing A4
  polybromo 1
  polycomb group ring finger 1
  rhomboid domain containing 1
  ring finger and CCCH-type domains 1
  sirtuin 7
  spire type actin nucleation factor 2
  syncoilin, intermediate filament protein
  THAP domain containing 3
  THO complex 2
  ubiquitin protein ligase E3 component n-recognin 5
  vir like m6A methyltransferase associated
  WW domain containing oxidoreductase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.