SMPD4, sphingomyelin phosphodiesterase 4

SMPD4, sphingomyelin phosphodiesterase 4

• The protein encoded by this gene is a sphingomyelinase that catalyzes the hydrolysis of membrane sphingomyelin to form phosphorylcholine and ceramide. This gene is activated by DNA damage, cellular stress, and tumor necrosis factor, but it is downregulated by wild-type p53. The encoded protein localizes to the endoplasmic reticulum and Golgi network. [provided by RefSeq, Mar 2017]

• Gene Synonyms (NEDMABA, NEDMEBA, NET13, NSMASE-3, NSMASE3, SKNY, sphingomyelin phosphodiesterase 4, neutral sphingomyelinase 3, neutral sphingomyelinase III, sphingomyelin phosphodiesterase 4, neutral membrane (neutral sphingomyelinase-3),)
• NCBI Gene ID: 55627
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B1PBA3
  UNIPROT ID#>>Q9NXE4
  UNIPROT ID#>>H7BXF4
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

sphingomyelin phosphodiesterase 4 interacts with:

• developmental pluripotency-associated 3
  EvC ciliary complex subunit 2
  forkhead box I2
  nucleoporin 107
  nucleoporin 107
  nucleoporin 98
  pleckstrin homology domain containing A4
  transmembrane protein 17
  unc-93 homolog B1, TLR signaling regulator

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.