MATR3, matrin 3

MATR3, matrin 3

• This gene encodes a nuclear matrix protein, which is proposed to stabilize certain messenger RNA species. Mutations of this gene are associated with distal myopathy 2, which often includes vocal cord and pharyngeal weakness. Alternatively spliced transcript variants, including read-through transcripts composed of the upstream small nucleolar RNA host gene 4 (non-protein coding) and matrin 3 gene sequence, have been identified. Pseudogenes of this gene are located on chromosomes 1 and X. [provided by RefSeq, Aug 2013]

• Gene Synonyms (matrin-3, vocal cord and pharyngeal weakness with distal myopathy, ALS21, MPD2, VCPDM,)
• NCBI Gene ID: 9782
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q9H4N1
  UNIPROT ID#>>B3KM87
  UNIPROT ID#>>B4DF66
  UNIPROT ID#>>P43243
  UNIPROT ID#>>A0A0R4J2E8
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

matrin 3 interacts with:

• A kinase (PRKA) anchor protein 8
  AAR2 splicing factor
  A-kinase anchoring protein 8
  A-kinase anchoring protein 8 like
  AKT interacting protein
  alkB homolog 3, alpha-ketoglutarate dependent dioxygenase
  Aly/REF export factor
  anterior gradient 2, protein disulphide isomerase family member
  ATPase family AAA domain containing 3A
  ATPase family AAA domain containing 3B
  autophagy related 16 like 1
  B9 domain containing 2
  BCLAF1 and THRAP3 family member 3
  bromodomain containing 7
  cap methyltransferase 1
  caveolae associated protein 3
  CDK5 regulatory subunit associated protein 1
  CDKN2A interacting protein
  cell cycle and apoptosis regulator 2
  centromere protein E
  centrosomal protein 250
  cereblon
  coiled-coil domain containing 8
  COP9 signalosome subunit 5
  COPI coat complex subunit epsilon
  cullin 7
  cullin associated and neddylation dissociated 1
  DEAD-box helicase 17
  DEAD-box helicase 28
  developmental pluripotency-associated 3
  DExH-box helicase 30
  DISC1 scaffold protein
  DnaJ heat shock protein family (Hsp40) member B6
  dpy-30 histone methyltransferase complex regulatory subunit
  dual specificity phosphatase 14
  epiplakin 1
  establishment of sister chromatid cohesion N-acetyltransferase 2
  eukaryotic translation initiation factor 2 alpha kinase 4
  family with sequence similarity 120A
  F-box and WD repeat domain containing 11
  F-box protein 7
  glutamate rich WD repeat containing 1
  glutathione S-transferase kappa 1
  GTP binding protein 4
  heterogeneous nuclear ribonucleoprotein A0
  heterogeneous nuclear ribonucleoprotein A3
  heterogeneous nuclear ribonucleoprotein A3
  heterogeneous nuclear ribonucleoprotein C like 1
  heterogeneous nuclear ribonucleoprotein D like
  heterogeneous nuclear ribonucleoprotein F
  heterogeneous nuclear ribonucleoprotein R
  heterogeneous nuclear ribonucleoprotein U like 1
  heterogeneous nuclear ribonucleoprotein U like 2
  HEXIM P-TEFb complex subunit 1
  histone H3 associated protein kinase
  insulin like growth factor 2 mRNA binding protein 1
  insulin like growth factor 2 mRNA binding protein 3
  integrin alpha FG-GAP repeat containing 1
  isoleucyl-tRNA synthetase 2, mitochondrial
  keratin 27
  KH RNA binding domain containing, signal transduction associated 1
  La ribonucleoprotein 1, translational regulator
  leucine rich pentatricopeptide repeat containing
  leucine rich repeat containing G protein-coupled receptor 4
  matrin 3
  mediator complex subunit 12
  methylphosphate capping enzyme
  methyltransferase like 14
  methyltransferase like 3
  microtubule associated protein 1 light chain 3 alpha
  mitochondrial ribosomal protein L19
  M-phase phosphoprotein 8
  Mtr4 exosome RNA helicase
  MYB binding protein 1a
  myelin expression factor 2
  myoferlin
  N-alpha-acetyltransferase 15, NatA auxiliary subunit
  NLR family pyrin domain containing 5
  NPR2 like, GATOR1 complex subunit
  nuclear receptor coactivator 5
  obscurin like cytoskeletal adaptor 1
  peptidylprolyl isomerase E
  periphilin 1
  PIH1 domain containing 1
  plakophilin 3
  pleckstrin homology and RhoGEF domain containing G4
  poly(A) binding protein cytoplasmic 1
  poly(A) specific ribonuclease subunit PAN2
  poly(rC) binding protein 3
  poly(U) binding splicing factor 60
  polypyrimidine tract binding protein 1
  polypyrimidine tract binding protein 2
  polypyrimidine tract binding protein 3
  pre-mRNA processing factor 6
  pre-mRNA processing factor 8
  proline rich 3
  proteasome activator subunit 3
  protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1
  PTEN induced kinase 1
  RAD50 double strand break repair protein
  RALY heterogeneous nuclear ribonucleoprotein
  ras related dexamethasone induced 1
  RBMX like 1
  replication timing regulatory factor 1
  ribosomal L1 domain containing 1
  ribosomal protein L13a
  ribosomal protein L26 like 1
  ribosomal RNA processing 7 homolog A
  ribosome biogenesis regulator 1 homolog
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  ring-box 1
  RNA 2',3'-cyclic phosphate and 5'-OH ligase
  RNA binding fox-1 homolog 2
  RNA binding motif protein 12B
  RNA binding motif protein 14
  RNA binding motif protein 15B
  RNA binding motif protein 4B
  RNA binding motif protein 6
  RNA binding motif protein 7
  RNA binding motif protein X-linked
  RNA polymerase III subunit B
  RNA transcription, translation and transport factor
  RuvB like AAA ATPase 2
  SAFB like transcription modulator
  seryl-tRNA synthetase 2, mitochondrial
  SET nuclear oncogene
  Sin3A associated protein 18
  sirtuin 6
  small nuclear ribonucleoprotein U5 subunit 200
  SMU1 DNA replication regulator and spliceosomal factor
  splicing factor 3a subunit 3
  splicing factor 3b subunit 1
  splicing factor 3b subunit 2
  staufen double-stranded RNA binding protein 2
  stomatin like 2
  structural maintenance of chromosomes 2
  structural maintenance of chromosomes 4
  structural maintenance of chromosomes flexible hinge domain containing 1
  SUB1 regulator of transcription
  sulfide quinone oxidoreductase
  SUMO specific peptidase 3
  SURP and G-patch domain containing 2
  SWI/SNF-related, matrix-associated actin-dependent regulator of chromatin, subfamily a, containing DEAD/H box 1
  synaptotagmin binding cytoplasmic RNA interacting protein
  TAR DNA binding protein
  testis specific 10
  thyroid hormone receptor associated protein 3
  TNF receptor superfamily member 21
  TNFAIP3 interacting protein 2
  transcription activation suppressor
  translocase of inner mitochondrial membrane 13
  tripartite motif containing 28
  TSR1 ribosome maturation factor
  U2 small nuclear RNA auxiliary factor 2
  ubiquilin 2
  unk zinc finger
  UTP14A small subunit processome component
  vir like m6A methyltransferase associated
  WW domain containing E3 ubiquitin protein ligase 1
  WW domain containing E3 ubiquitin protein ligase 2
  WW domain containing oxidoreductase
  Y box protein 1
  Yes1 associated transcriptional regulator
  YLP motif containing 1
  zinc finger CCCH-type containing, antiviral 1
  zinc finger CCHC-type containing 8
  zinc finger containing ubiquitin peptidase 1
  zinc finger FYVE-type containing 21
  zinc finger protein 106
  zinc finger protein 326
  zinc finger protein 638
  zinc finger protein 668
  zinc finger RNA binding protein

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.