IGF2BP3, insulin like growth factor 2 mRNA binding protein 3

IGF2BP3, insulin like growth factor 2 mRNA binding protein 3

• The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008]

• Gene Synonyms (CT98, IMP-3, IMP3, KOC, KOC1, VICKZ3, insulin-like growth factor 2 mRNA-binding protein 3, IGF-II mRNA-binding protein 3, IGF2 mRNA-binding protein 3, KH domain containing protein overexpressed in cancer, VICKZ family member 3, cancer/testis antigen 98,)
• NCBI Gene ID: 10643
• Species: Homo sapiens (Human)
• UNIPROT ID#>>O00425
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

insulin like growth factor 2 mRNA binding protein 3 interacts with:

• apolipoprotein B mRNA editing enzyme catalytic subunit 3D
  BCL2 like 14
  bromodomain containing 7
  cap methyltransferase 1
  chromobox 6
  chromobox 8
  coiled-coil domain containing 8
  COP9 signalosome subunit 5
  C-type lectin domain containing 14A
  cullin associated and neddylation dissociated 1
  decapping enzyme, scavenger
  DExH-box helicase 57
  DIMT1 rRNA methyltransferase and ribosome maturation factor
  enhancer of mRNA decapping 4
  F-box protein 6
  G1 to S phase transition 2
  heterogeneous nuclear ribonucleoprotein U like 2
  histone deacetylase 11
  KH RNA binding domain containing, signal transduction associated 2
  La ribonucleoprotein 7, transcriptional regulator
  lin-28 homolog A
  methylphosphate capping enzyme
  mitochondrial ribosomal protein S34
  NADH:ubiquinone oxidoreductase complex assembly factor 4
  negative elongation factor complex member B
  obscurin like cytoskeletal adaptor 1
  OTU deubiquitinase 4
  peter pan homolog
  PIH1 domain containing 2
  pleckstrin homology domain containing A4
  poly(U) binding splicing factor 60
  potassium channel tetramerization domain containing 10
  PTEN induced kinase 1
  ribosomal protein L26 like 1
  ribosome binding protein 1
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  ring finger protein 123
  ring finger protein 31
  RIO kinase 1
  RNA 2',3'-cyclic phosphate and 5'-OH ligase
  RNA transcription, translation and transport factor
  sirtuin 7
  TNFAIP3 interacting protein 2
  WW domain containing oxidoreductase
  Y box protein 1
  zinc finger CCCH-type containing 7A
  zinc finger protein 746

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.