PAN2, poly(A) specific ribonuclease subunit PAN2

PAN2, poly(A) specific ribonuclease subunit PAN2

• This gene encodes a deadenylase that functions as the catalytic subunit of the polyadenylate binding protein dependent poly(A) nuclease complex. The encoded protein is a magnesium dependent 3' to 5' exoribonuclease that is involved in the degradation of cytoplasmic mRNAs. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

• Gene Synonyms (PAN2-PAN3 deadenylation complex catalytic subunit PAN2, PAB-dependent poly(A)-specific ribonuclease subunit 2, PAB-dependent poly(A)-specific ribonuclease subunit PAN2, PAB1P-dependent poly(A)-nuclease, PAB1P-dependent poly(A)-specific ribonuclease, PABP-dependent poly(A) nuclease 2, PAN deadenylation complex catalytic subunit 2, PAN deadenylation complex subunit 2, PAN2 poly(A) specific ribonuclease subunit homolog, PAN2 polyA specific ribonuclease subunit, inactive ubiquitin carboxyl-terminal hydrolase 52, poly(A)-nuclease deadenylation complex subunit 2, ubiquitin specific peptidase 52, ubiquitin specific protease 52, USP52,)
• NCBI Gene ID: 9924
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q504Q3
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

poly(A) specific ribonuclease subunit PAN2 interacts with:

• 5'-3' exoribonuclease 2
  actin related protein 2/3 complex subunit 1B
  actin related protein 3B
  Aly/REF export factor
  anti-silencing function 1A histone chaperone
  anti-silencing function 1B histone chaperone
  biogenesis of ribosomes BRX1
  bolA family member 2
  brain abundant membrane attached signal protein 1
  carboxymethylenebutenolidase homolog
  chaperonin containing TCP1 subunit 2
  chaperonin containing TCP1 subunit 4
  chaperonin containing TCP1 subunit 5
  chaperonin containing TCP1 subunit 7
  chaperonin containing TCP1 subunit 8
  chromosome 15 open reading frame 39
  COBW domain containing 2
  coiled-coil-helix-coiled-coil-helix domain containing 3
  coronin 1C
  cytoplasmic linker associated protein 2
  dedicator of cytokinesis 7
  dermcidin
  DNA polymerase delta interacting protein 3
  DnaJ heat shock protein family (Hsp40) member A2
  EBF transcription factor 3
  EF-hand domain family member D1
  EF-hand domain family member D2
  ELKS/RAB6-interacting/CAST family member 1
  eukaryotic translation initiation factor 4E nuclear import factor 1
  G protein subunit beta 4
  G protein subunit gamma 12
  H2B.S histone 1
  helicase with zinc finger
  heterogeneous nuclear ribonucleoprotein A3
  influenza virus NS1A binding protein
  insulin like growth factor 2 mRNA binding protein 1
  KIAA1671
  lamin B2
  leucine rich repeats and calponin homology domain containing 3
  leucine zipper tumor suppressor 2
  LIM domain and actin binding 1
  LSM1 homolog, mRNA degradation associated
  MARCKS like 1
  mex-3 RNA binding family member C
  mitochondrial ribosomal protein L39
  MYC binding protein
  myosin heavy chain 14
  myosin light chain 12B
  myosin light chain 6B
  myosin phosphatase Rho interacting protein
  myosin VC
  myosin XVIIIA
  nexilin F-actin binding protein
  nischarin
  NSE2 (MMS21) homolog, SMC5-SMC6 complex SUMO ligase
  nucleoporin 50
  poly(A) binding protein cytoplasmic 1
  poly(A) specific ribonuclease subunit PAN3
  polycomb group ring finger 3
  polycomb group ring finger 5
  POM121 transmembrane nucleoporin C
  potassium channel tetramerization domain containing 5
  protein arginine methyltransferase 5
  protein kinase C and casein kinase substrate in neurons 3
  quiescin sulfhydryl oxidase 2
  RAD50 double strand break repair protein
  RANBP2-type and C3HC4-type zinc finger containing 1
  RAS related 2
  retinoic acid induced 14
  ribosomal protein L13a
  ribosomal protein L26 like 1
  ribosomal protein L35
  ribosomal protein L36
  ring finger protein 144B
  RIO kinase 1
  RNA binding motif protein X-linked
  RuvB like AAA ATPase 2
  serine and arginine rich splicing factor 8
  serine/arginine repetitive matrix 2
  serine/threonine kinase 38 like
  SERPINE1 mRNA binding protein 1
  SH3 domain binding glutamate rich protein like 2
  sosondowah ankyrin repeat domain family member A
  sperm antigen with calponin homology and coiled-coil domains 1
  sperm antigen with calponin homology and coiled-coil domains 1 like
  sphingomyelin phosphodiesterase acid like 3B
  splicing factor 3b subunit 6
  stimulator of interferon response cGAMP interactor 1
  tet methylcytosine dioxygenase 2
  thyroid hormone receptor associated protein 3
  TRAF-type zinc finger domain containing 1
  transducer of ERBB2, 1
  transducer of ERBB2, 2
  translocase of inner mitochondrial membrane 50
  trinucleotide repeat containing adaptor 6A
  trinucleotide repeat containing adaptor 6C
  tripartite motif containing 35
  tropomodulin 2
  tropomodulin 3
  tubulin alpha 1b
  tubulin beta 4B class IVb
  tubulin beta class I
  ubiquitin domain containing 1
  uveal autoantigen with coiled-coil domains and ankyrin repeats
  WD repeat domain 77
  zinc finger protein 234

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.