LSM1, LSM1 homolog, mRNA degradation associated

LSM1, LSM1 homolog, mRNA degradation associated

• This gene encodes a member of the LSm family of RNA-binding proteins. LSm proteins form stable heteromers that bind specifically to the 3'-terminal oligo(U) tract of U6 snRNA and may play a role in pre-mRNA splicing by mediating U4/U6 snRNP formation. Increased expression of this gene may play a role in cellular transformation and the progression of several malignancies including lung cancer, mesothelioma and breast cancer. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Nov 2011]

• Gene Synonyms (U6 snRNA-associated Sm-like protein LSm1, LSM1 homolog, U6 small nuclear RNA associated, LSM1 mRNA degradation associated, LSM1, U6 small nuclear RNA associated, LSM1-like protein U6 small nuclear RNA associated, cancer-associated Sm protein, cancer-associated Sm-like protein, small nuclear ribonuclear CaSm, CASM, YJL124C,)
• NCBI Gene ID: 27257
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A0S2Z590
  UNIPROT ID#>>O15116
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

LSM1 homolog, mRNA degradation associated interacts with:

• anterior gradient 3, protein disulphide isomerase family member
  brain expressed X-linked 5
  death associated protein like 1
  exosome component 6
  LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
  LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated
  LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
  mitochondrial coiled-coil domain 1
  PAT1 homolog 1, processing body mRNA decay factor
  PCI domain containing 2
  prolyl 3-hydroxylase 1
  sosondowah ankyrin repeat domain family member A
  transmembrane protein 214
  VPS11 core subunit of CORVET and HOPS complexes

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.