POLR3B, RNA polymerase III subunit B

POLR3B, RNA polymerase III subunit B

• This gene encodes the second largest subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The largest subunit and the encoded protein form the catalytic center of RNA polymerase III. Mutations in this gene are a cause of hypomyelinating leukodystrophy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]

• Gene Synonyms (C128, HLD8, INMAP, RPC2, DNA-directed RNA polymerase III subunit RPC2, DNA-directed RNA polymerase III 127.6 kDa polypeptide, DNA-directed RNA polymerase III subunit B, RNA polymerase III subunit C2, interphase nucleus and mitotic apparatus associated protein, polymerase (RNA) III (DNA directed) polypeptide B, polymerase (RNA) III subunit B,)
• NCBI Gene ID: 55703
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q7Z3R8
  UNIPROT ID#>>Q9NW08
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

RNA polymerase III subunit B interacts with:

• apolipoprotein B mRNA editing enzyme catalytic subunit 3D
  ARP1 actin-related protein 1B, centractin beta
  catenin beta like 1
  DSN1 component of MIS12 kinetochore complex
  importin 9
  MAF1 homolog, negative regulator of RNA polymerase III
  mitochondrial ribosomal protein L17
  N(alpha)-acetyltransferase 11, NatA catalytic subunit
  phosphopantothenoylcysteine synthetase
  pleckstrin homology domain containing A4
  RIO kinase 1
  RNA polymerase I subunit B
  RNA polymerase II associated protein 2
  RNA polymerase III subunit B
  RNA polymerase III subunit E
  RNA polymerase III subunit GL
  RNA polymerase III subunit H
  RuvB-like protein 1
  TSR1 ribosome maturation factor

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.