ARHGEF7, Rho guanine nucleotide exchange factor 7

ARHGEF7, Rho guanine nucleotide exchange factor 7

• This gene encodes a protein that belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Mar 2016]

• Gene Synonyms (rho guanine nucleotide exchange factor 7, PAK-interacting exchange factor beta, Rho guanine nucleotide exchange factor (GEF) 7, SH3 domain-containing proline-rich protein, BETA-PIX, COOL-1, COOL1, Nbla10314, P50, P50BP, P85, P85COOL1, P85SPR, PAK3, PIXB,)
• NCBI Gene ID: 8874
• Species: Homo sapiens (Human)
• UNIPROT ID#>>B7Z6G2
  UNIPROT ID#>>E9PDQ5
  UNIPROT ID#>>Q5W9H1
  UNIPROT ID#>>Q14155
  UNIPROT ID#>>A0A024RDY9
  UNIPROT ID#>>B7Z344
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Rho guanine nucleotide exchange factor 7 interacts with:

• CD244 molecule
  elongation factor Tu GTP binding domain containing 2
  erbb2 interacting protein
  exocyst complex component 1
  F-box protein 28
  GIT ArfGAP 1
  GIT ArfGAP 2
  innate immunity activator
  itchy E3 ubiquitin protein ligase
  kelch like family member 2
  leucine rich repeat kinase 2
  leupaxin
  lysine demethylase 2A
  mediator complex subunit 4
  myelin basic protein
  NADPH oxidase 1
  NCK interacting protein with SH3 domain
  POTE ankyrin domain family member B3
  protein kinase D2
  protein phosphatase, Mg2+/Mn2+ dependent 1E
  protein phosphatase, Mg2+/Mn2+ dependent 1F
  Rac/Cdc42 guanine nucleotide exchange factor 6
  Rho guanine nucleotide exchange factor 7
  scribble planar cell polarity protein
  SH3 and multiple ankyrin repeat domains 1
  SH3 and multiple ankyrin repeat domains 2
  SH3 and multiple ankyrin repeat domains 3
  solute carrier family 33 member 1
  sorting nexin 27
  syncoilin, intermediate filament protein
  tubulin beta 3 class III
  vir like m6A methyltransferase associated
  zinc finger and BTB domain containing 48

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.