TRIM21, tripartite motif containing 21

TRIM21, tripartite motif containing 21

• This gene encodes a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The encoded protein is part of the RoSSA ribonucleoprotein, which includes a single polypeptide and one of four small RNA molecules. The RoSSA particle localizes to both the cytoplasm and the nucleus. RoSSA interacts with autoantigens in patients with Sjogren syndrome and systemic lupus erythematosus. Alternatively spliced transcript variants for this gene have been described but the full-length nature of only one has been determined. [provided by RefSeq, Jul 2008]

• Gene Synonyms (E3 ubiquitin-protein ligase TRIM21, 52 kDa Ro protein, 52 kDa ribonucleoprotein autoantigen Ro/SS-A, RING finger protein 81, RING-type E3 ubiquitin transferase TRIM21, Ro/SSA 52kDa, SS-A, Sicca syndrome antigen A, Sjogren syndrome antigen A1 (52kDa, ribonucleoprotein autoantigen SS-A/Ro), ro(SS-A), sjoegren syndrome type A antigen, tripartite motif-containing protein 21, RNF81, RO52, Ro/SSA, SSA, SSA1,)
• NCBI Gene ID: 6737
• Species: Homo sapiens (Human)
• UNIPROT ID#>>P19474
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

tripartite motif containing 21 interacts with:

• agrin
  argonaute RISC catalytic component 3
  argonaute RISC component 4
  ariadne RBR E3 ubiquitin protein ligase 2
  armadillo repeat containing 12
  BAG cochaperone 6
  beclin 1
  caspase 8 associated protein 2
  cereblon
  chromobox 4
  c-src tyrosine kinase
  cullin 1
  CWC25 spliceosome associated protein homolog
  DAZ interacting zinc finger protein 3
  DDB1 and CUL4 associated factor 4 like 2
  decapping enzyme, scavenger
  decapping mRNA 2
  developmental pluripotency associated 4
  DNA methyltransferase 1 associated protein 1
  exocyst complex component 8
  Fas apoptotic inhibitory molecule 2
  Fas associated factor 1
  Fas associated via death domain
  F-box and WD repeat domain containing 11
  F-box protein 6
  formin homology 2 domain containing 1
  G3BP stress granule assembly factor 1
  GABA type A receptor associated protein like 1
  GABA type A receptor associated protein like 2
  GABA type A receptor-associated protein
  germ cell-less 1, spermatogenesis associated
  gigaxonin
  GRB2 related adaptor protein
  guanine monophosphate synthase
  H3 clustered histone 6
  HAUS augmin like complex subunit 2
  HEXIM P-TEFb complex subunit 1
  histone deacetylase 6
  immunoglobulin like and fibronectin type III domain containing 1
  integrin alpha FG-GAP repeat containing 1
  IQ motif containing B1
  jun B proto-oncogene
  La ribonucleoprotein 7, transcriptional regulator
  ligand of numb-protein X 1
  metadherin
  methylphosphate capping enzyme
  microtubule associated protein 1 light chain 3 alpha
  microtubule associated protein 1 light chain 3 beta
  microtubule associated protein 1 light chain 3 gamma
  MINDY lysine 48 deubiquitinase 4
  mitochondrial antiviral signaling protein
  Nanog homeobox
  NGG1 interacting factor 3 like 1
  N-myc and STAT interactor
  nuclear receptor coactivator 1
  nuclear receptor coactivator 3
  OTU deubiquitinase, ubiquitin aldehyde binding 2
  poly(A) specific ribonuclease subunit PAN2
  protein arginine methyltransferase 5
  RANBP2-type and C3HC4-type zinc finger containing 1
  ring finger and CCCH-type domains 1
  ring finger and CCCH-type domains 2
  ring finger protein 111
  ring finger protein 38
  Ro60, Y RNA binding protein
  sequestosome 1
  SET domain containing 1A, histone lysine methyltransferase
  spindle apparatus coiled-coil protein 1
  SUZ12 polycomb repressive complex 2 subunit
  TANK binding kinase 1
  t-complex 11 like 1
  tensin 4
  tet methylcytosine dioxygenase 2
  thioredoxin 2
  transformed mouse 3T3 cell double minute 2
  tripartite motif containing 21
  tripartite motif containing 3
  tripartite motif containing 39
  tripartite motif containing 5
  tripartite motif containing 8
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta
  ubiquitin C
  ubiquitin conjugating enzyme E2 C
  ubiquitin conjugating enzyme E2 D1
  ubiquitin conjugating enzyme E2 D2
  ubiquitin conjugating enzyme E2 E1
  ubiquitin conjugating enzyme E2 H
  ubiquitin conjugating enzyme E2 I
  ubiquitin conjugating enzyme E2 L3
  ubiquitin conjugating enzyme E2 M
  ubiquitin conjugating enzyme E2 N
  ubiquitin conjugating enzyme E2 V2
  ubiquitin conjugating enzyme E2 W
  ubiquitin specific peptidase 15
  ubiquitin specific peptidase 19
  ubiquitin specific peptidase 2
  ubiquitin specific peptidase 4
  unc-51 like autophagy activating kinase 1
  valosin containing protein
  vir like m6A methyltransferase associated
  VPS9 domain containing 1
  VRK serine/threonine kinase 1
  XIAP associated factor 1
  YJU2 splicing factor homolog
  zinc finger and BTB domain containing 16
  zinc finger protein 598, E3 ubiquitin ligase
  zinc finger protein, FOG family member 1

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.