USP4, ubiquitin specific peptidase 4

USP4, ubiquitin specific peptidase 4

• The protein encoded by this gene is a protease that deubiquitinates target proteins such as ADORA2A and TRIM21. The encoded protein shuttles between the nucleus and cytoplasm and is involved in maintaining operational fidelity in the endoplasmic reticulum. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

• Gene Synonyms (ubiquitin carboxyl-terminal hydrolase 4, deubiquitinating enzyme 4, ubiquitin carboxyl-terminal esterase 4, ubiquitin specific peptidase 4 (proto-oncogene), ubiquitin specific protease 4 (proto-oncogene), ubiquitin thioesterase 4, ubiquitin thiolesterase 4, ubiquitin-specific processing protease 4, ubiquitous nuclear protein homolog, UNP, Unph,)
• NCBI Gene ID: 7375
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024R2T0
  UNIPROT ID#>>A0A024R2X6
  UNIPROT ID#>>Q13107
  UNIPROT ID#>>Q08AK7
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

ubiquitin specific peptidase 4 interacts with:

• A-kinase anchoring protein 7
  aspartyl aminopeptidase
  ATPase H+ transporting V0 subunit d1
  B-box and SPRY domain containing
  BRCA1 associated protein
  calcium binding protein 1
  cancer/testis antigen 55
  chromosome 6 open reading frame 141
  cullin 4B
  cytosolic iron-sulfur assembly component 2B
  decapping mRNA 1A
  decapping mRNA 1B
  DExD/H-box helicase 58
  engulfment and cell motility 1
  enhancer of mRNA decapping 3
  eukaryotic translation initiation factor 4E family member 2
  exocyst complex component 1
  HECT, UBA and WWE domain containing E3 ubiquitin protein ligase 1
  hyaluronan synthase 2
  inhibitory synaptic factor 2A
  LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated
  LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
  LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated
  LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated
  LSM8 homolog, U6 small nuclear RNA associated
  methylphosphate capping enzyme
  mitochondrial antiviral signaling protein
  mitogen-activated protein kinase kinase kinase 6
  nemo like kinase
  NPC intracellular cholesterol transporter 2
  nucleolar and coiled-body phosphoprotein 1
  peptidylprolyl isomerase H
  pleckstrin homology domain containing A4
  pre-mRNA processing factor 19
  pre-mRNA processing factor 3
  pre-mRNA processing factor 31
  pre-mRNA processing factor 4
  protein tyrosine phosphatase 4A3
  RAB30, member RAS oncogene family
  RAD50 double strand break repair protein
  receptor interacting serine/threonine kinase 1
  ring finger protein 19B
  ripply transcriptional repressor 2
  RNA binding protein with serine rich domain 1
  SLX1 homolog A, structure-specific endonuclease subunit
  spindle apparatus coiled-coil protein 1
  spliceosome associated factor 3, U4/U6 recycling protein
  STN1 subunit of CST complex
  t-complex 10 like
  terminal nucleotidyltransferase 5A
  terminal uridylyl transferase 1, U6 snRNA-specific
  transcription elongation factor A like 1
  tripartite motif containing 54
  tripartite motif containing 55
  tripartite motif containing 63
  tRNA methyltransferase 1
  tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta
  ubiquitin specific peptidase 1
  ubiquitin specific peptidase 11
  ubiquitin specific peptidase 15
  ubiquitin specific peptidase 19
  ubiquitin specific peptidase 21
  ubiquitin specific peptidase 28
  ubiquitin specific peptidase 32
  ubiquitin specific peptidase 4
  vir like m6A methyltransferase associated

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.