RIPK1, receptor interacting serine/threonine kinase 1

RIPK1, receptor interacting serine/threonine kinase 1

• This gene encodes a member of the receptor-interacting protein (RIP) family of serine/threonine protein kinases. The encoded protein plays a role in inflammation and cell death in response to tissue damage, pathogen recognition, and as part of developmental regulation. RIPK1/RIPK3 kinase-mediated necrosis is referred to as necroptosis. Genetic disruption of this gene in mice results in death shortly after birth. [provided by RefSeq, Aug 2017]

• Gene Synonyms (receptor-interacting serine/threonine-protein kinase 1, cell death protein RIP, receptor (TNFRSF)-interacting serine-threonine kinase 1, receptor-interacting protein 1, receptor-interacting protein kinase 1, serine/threonine-protein kinase RIP, AIEFL, IMD57, RIP, RIP-1, RIP1,)
• NCBI Gene ID: 8737
• Species: Homo sapiens (Human)
• UNIPROT ID#>>A0A024QZU0
  UNIPROT ID#>>Q13546
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

receptor interacting serine/threonine kinase 1 interacts with:

• adaptor related protein complex 1 subunit mu 2
  angiopoietin like 8
  autophagy related 5
  autophagy related 7
  CAP-Gly domain containing linker protein 3
  CASP2 and RIPK1 domain containing adaptor with death domain
  CASP8 and FADD like apoptosis regulator
  CDC42 binding protein kinase beta
  coiled-coil domain containing 50
  cytochrome c oxidase subunit 5A
  DAB2 interacting protein
  egl-9 family hypoxia inducible factor 3
  Fas associated via death domain
  HECT and RLD domain containing E3 ubiquitin protein ligase 2
  inhibitor of nuclear factor kappa B kinase subunit epsilon
  itchy E3 ubiquitin protein ligase
  KH RNA binding domain containing, signal transduction associated 1
  leucine rich repeat kinase 2
  metadherin
  mitogen-activated protein kinase kinase kinase 14
  mixed lineage kinase domain like pseudokinase
  N-terminal asparagine amidase
  nucleotide binding oligomerization domain containing 2
  NUMB like endocytic adaptor protein
  optineurin
  OTU deubiquitinase 1
  p53-induced death domain protein 1
  pellino E3 ubiquitin protein ligase 1
  PYD and CARD domain containing
  RANBP2-type and C3HC4-type zinc finger containing 1
  receptor interacting serine/threonine kinase 1
  receptor interacting serine/threonine kinase 2
  receptor interacting serine/threonine kinase 3
  ring finger and FYVE like domain containing E3 ubiquitin protein ligase
  ring finger protein 11
  ring finger protein 216
  ring finger protein 31
  sequestosome 1
  TANK binding kinase 1
  Tax1 binding protein 1
  TGF-beta activated kinase 1 (MAP3K7) binding protein 1
  TGF-beta activated kinase 1 (MAP3K7) binding protein 2
  thrombospondin type 1 domain containing 4
  TNF receptor superfamily member 10a
  TNF receptor superfamily member 10b
  TNF superfamily member 10
  TNFAIP3 interacting protein 2
  toll like receptor adaptor molecule 1
  transient receptor potential cation channel subfamily C member 4 associated protein
  tripartite motif containing 38
  ubiquitin specific peptidase 2
  ubiquitin specific peptidase 20
  ubiquitin specific peptidase 21
  WD repeat domain 48
  XIAP associated factor 1
  YOD1 deubiquitinase

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.