TNFRSF10B, TNF receptor superfamily member 10b

TNFRSF10B, TNF receptor superfamily member 10b

• The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]

• Gene Synonyms (tumor necrosis factor receptor superfamily member 10B, Fas-like protein, TNF-related apoptosis-inducing ligand receptor 2, apoptosis inducing protein TRICK2A/2B, apoptosis inducing receptor TRAIL-R2, cytotoxic TRAIL receptor-2, death domain containing receptor for TRAIL/Apo-2L, death receptor 5, p53-regulated DNA damage-inducible cell death receptor(killer), tumor necrosis factor receptor superfamily, member 10b, tumor necrosis factor receptor-like protein ZTNFR9, CD262, DR5, KILLER, KILLER/DR5, TRAIL-R2, TRAILR2, TRICK2, TRICK2A, TRICK2B, TRICKB, ZTNFR9,)
• NCBI Gene ID: 8795
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q7Z2I8
  UNIPROT ID#>>O14763
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

TNF receptor superfamily member 10b interacts with:

• arrestin domain containing 3
  Bet1 golgi vesicular membrane trafficking protein
  bone morphogenetic protein receptor, type 1A
  CASP8 and FADD like apoptosis regulator
  cytoskeleton associated protein 4
  FLVCR heme transporter 1
  glycoprotein integral membrane 1
  HEPACAM family member 2
  hepatitis A virus cellular receptor 1
  itchy E3 ubiquitin protein ligase
  leucine rich repeats and IQ motif containing 1
  lipolysis stimulated lipoprotein receptor
  lysosomal protein transmembrane 4 beta
  MHC class I polypeptide-related sequence A
  Nedd4 family interacting protein 1
  peptidyl-tRNA hydrolase 2
  PRA1 domain family member 2
  ring finger protein 11
  ring finger protein 149
  secretory carrier membrane protein 1
  solute carrier family 15 member 4
  syntaxin 12
  tetraspanin 3
  TNF receptor superfamily member 10a
  TNF receptor superfamily member 13B
  translocase of inner mitochondrial membrane 50
  transmembrane protein 17
  transmembrane protein 214
  transmembrane protein 223
  transmembrane protein 231
  transmembrane protein 31
  vesicle associated membrane protein 3
  zinc finger DHHC-type palmitoyltransferase 15

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.