MICA, MHC class I polypeptide-related sequence A

MICA, MHC class I polypeptide-related sequence A

• This gene encodes the highly polymorphic major histocompatability complex class I chain-related protein A. The protein product is expressed on the cell surface, although unlike canonical class I molecules it does not seem to associate with beta-2-microglobulin. It is a ligand for the NKG2-D type II integral membrane protein receptor. The protein functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells. Variations in this gene have been associated with susceptibility to psoriasis 1 and psoriatic arthritis, and the shedding of MICA-related antibodies and ligands is involved in the progression from monoclonal gammopathy of undetermined significance to multiple myeloma. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2014]

• Gene Synonyms (MIC-A, PERB11.1, MHC class I polypeptide-related sequence A, HLA class I antigen, MHC class I chain-related protein A, MHC class I related chain A, MHC class I related sequence A, major histocompatibility complex class I chain-related protein A, stress inducible class I homolog, truncated MHC class I polypeptide-related sequence A, truncated MICA,)
• NCBI Gene ID: 100507436
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q96QC4
  UNIPROT ID#>>A0A024RCL3
  UNIPROT ID#>>A0A0G2JJ55
  UNIPROT ID#>>Q29983
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

MHC class I polypeptide-related sequence A interacts with:

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