FADD, Fas associated via death domain

FADD, Fas associated via death domain

• The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq, Jul 2008]

• Gene Synonyms (FAS-associated death domain protein, Fas (TNFRSF6)-associated via death domain, Fas-associating death domain-containing protein, Fas-associating protein with death domain, growth-inhibiting gene 3 protein, mediator of receptor-induced toxicity, GIG3, MORT1,)
• NCBI Gene ID: 8772
• Species: Homo sapiens (Human)
• UNIPROT ID#>>Q13158
• View the NCBI Database for this Gene »

Gene products are often involved in multiple pathways and networks within a living cell. Learn more about other interacting partners.

Fas associated via death domain interacts with:

• autophagy related 12
  autophagy related 5
  CAP-Gly domain containing linker protein 3
  CASP8 and FADD like apoptosis regulator
  caspase 8 associated protein 2
  coiled-coil domain containing 50
  creatine kinase, mitochondrial 1A
  DEAD-box helicase 24
  death effector domain containing
  DNA damage inducible transcript 4 like
  dynein axonemal assembly factor 1
  ectodysplasin A receptor
  ectodysplasin A2 receptor
  EH domain containing 1
  erythrocyte membrane protein band 4.1 like 4B
  exportin 5
  Fas (TNF receptor superfamily member 6)
  Fas associated factor 1
  Fas associated via death domain
  golgin A7 family member B
  homeodomain interacting protein kinase 3
  interleukin 37
  KH RNA binding domain containing, signal transduction associated 1
  kinesin family member 2C
  leucine rich repeat and coiled-coil centrosomal protein 1
  leucine rich repeat kinase 2
  makorin ring finger protein 1
  methyl-CpG binding domain 4, DNA glycosylase
  mitochondrial antiviral signaling protein
  MOB family member 4, phocein
  NAD(P)HX epimerase
  nascent polypeptide-associated complex alpha polypeptide
  neuron derived neurotrophic factor
  NLR family CARD domain containing 4
  nucleolar protein 3
  nucleoporin 42
  NUT family member 2F
  p53-induced death domain protein 1
  Parkinsonism associated deglycase
  peroxiredoxin 4
  ralA binding protein 1
  ras homolog family member Q
  receptor interacting serine/threonine kinase 3
  ring finger protein 41
  RING1 and YY1 binding protein
  sequestosome 1
  sidekick cell adhesion molecule 2
  solute carrier family 7 member 11
  sphingosine-1-phosphate receptor 2
  STIP1 homology and U-box containing protein 1
  TGF-beta activated kinase 1 (MAP3K7) binding protein 1
  TNF receptor superfamily member 10a
  TNF receptor superfamily member 10b
  TNFAIP3 interacting protein 1
  TRAF family member associated NFKB activator
  tubulin polymerization promoting protein
  unc-51 like kinase 3
  zinc finger CCHC-type containing 12
  zinc finger MYM-type containing 5

Paste a protein or nucleic acid sequence in the box below to confirm that it matches this gene’s reference sequence(s). Click on a link under RELATED ORF CLONES to see how a sequence matches to an experimentally-validated ORF clone.